Are 25 SNPs from the CARDIoGRAM study associated with ischaemic stroke?
H Lövkvist1, M Sjögren, P Höglund
1Department of Clinical Sciences, Lund University, Lund, Sweden. hakan.lovkvist@skane.se
European Journal of Neurology
|May 2, 2013
Summary
This study investigated genetic variants associated with coronary artery disease (CAD) for their link to ischaemic stroke (IS). Only one SNP on chromosome 9p21.3 showed a significant association with IS and large-vessel disease.
Area of Science:
- Genetics
- Cardiovascular Medicine
- Neurology
Background:
- The Coronary Artery Disease Genome-Wide Replication and Meta-Analysis Study (CARDIoGRAM) identified 25 single-nucleotide polymorphisms (SNPs) linked to coronary artery disease (CAD) risk.
- Shared vascular risk factors between CAD and ischaemic stroke (IS) suggest potential overlap in genetic susceptibility.
Purpose of the Study:
- To investigate whether 25 CAD-associated SNPs are also associated with overall IS or its pathogenetic subtypes.
- To evaluate the predictive value of genetic risk scores (GRSs) derived from these SNPs for IS.
Main Methods:
- A candidate gene study was conducted with 3986 IS patients and 2459 controls.
- Allelic association analysis and logistic regression were used to examine 25 CAD-associated SNPs.
- Weighted and unweighted genetic risk scores (GRSs) were analyzed for association with IS and its subtypes (large-vessel disease, small-vessel disease, cardioembolic stroke).
Main Results:
- SNP rs4977574 on chromosome 9p21.3 was significantly associated with overall IS (OR=1.12) and large-vessel disease (LVD) (OR=1.36).
- No other tested SNP showed a significant association with IS or its subtypes.
- Genetic risk scores did not demonstrate a significant effect on IS or its subtypes.
Conclusions:
- This study confirms the association of chromosome 9p21.3 SNPs with IS, but found no significant links between other CAD-susceptible genetic variants and IS.
- Genetic risk scores composed of these CAD-associated variants do not predict IS or its pathogenetic subtypes in a large cohort.
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