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Updated: May 11, 2026

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16
06:03

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16

Published on: July 15, 2019

Hand, foot, and mouth disease caused by coxsackievirus A6, Thailand, 2012

Jiratchaya Puenpa1, Thaweesak Chieochansin, Piyada Linsuwanon

  • 1Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Emerging Infectious Diseases
|May 2, 2013
PubMed

Insights

Coxsackievirus A6 caused a large hand, foot, and mouth disease (HFMD) outbreak in Thailand in 2012. Monitoring HFMD causes is crucial for effective prevention and control strategies.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Hand, foot, and mouth disease (HFMD) is a common infectious illness in Thailand.
  • Enterovirus 71 and coxsackievirus A16 are typically identified as the causative agents of HFMD.
  • A significant HFMD outbreak occurred in Thailand between June and August 2012.

Purpose of the Study:

  • To identify the specific enterovirus responsible for the 2012 HFMD outbreak in Thailand.
  • To inform public health strategies for managing future HFMD outbreaks.

Main Methods:

  • Patient specimens from the 2012 HFMD outbreak were collected and analyzed.
  • Enterovirus typing was performed to identify the causative viral strain.

Main Results:

  • Coxsackievirus A6 was identified as the primary etiological agent of the 2012 HFMD outbreak.
  • This finding contrasts with the usual identification of enterovirus 71 or coxsackievirus A16.

Conclusions:

  • Coxsackievirus A6 emerged as a significant cause of HFMD in Thailand during the 2012 outbreak.
  • Continuous surveillance of HFMD causative agents is essential for timely and effective disease control.

Keywords:
hand, foot, and mouth diseaseherpangina, enterovirus 71, coxsackievirus A6, coxsackievirus A16, Thailand, viruses

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