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Neuropsychiatric deep brain stimulation for translational neuroimaging
Anna Höflich1, Markus Savli, Erika Comasco
1Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria.
Neuroimage
|May 2, 2013
Summary
This study created a standardized database of deep brain stimulation (DBS) targets for psychiatric disorders like OCD and depression. This enables better comparison of DBS with neuroimaging data for improved treatment strategies.
Area of Science:
- Neuroimaging
- Neurosurgery
- Psychiatry
Background:
- Deep brain stimulation (DBS) offers unique insights into psychiatric disorders.
- Heterogeneity in DBS study data hinders comprehensive analysis.
- Standardized DBS target data is crucial for advancing neuroimaging research in psychiatry.
Purpose of the Study:
- To create a standardized database of DBS targets for obsessive-compulsive disorder (OCD), treatment-resistant depression (TRD), and Gilles de la Tourette syndrome (GTS).
- To enable topological comparisons between neuroimaging results and stimulation areas.
- To improve the comparability of neuroimaging data with surgical targets for DBS.
Main Methods:
- Systematic literature research of peer-reviewed publications until 2012.
- Inclusion of 84 studies with approximately 296 patients.
- Translation of stimulation data from 37 studies (202 patients) into MNI stereotactic space.
Main Results:
- A comprehensive database of DBS targets in MNI stereotactic coordinates was established.
- The database facilitates comparisons with functional, structural, and molecular neuroimaging data.
- Identified key DBS targets for OCD, TRD, and GTS.
Conclusions:
- The standardized DBS target database enhances the comparability of neuroimaging studies.
- This resource can inform the definition of new DBS targets and refine existing ones.
- Facilitates investigation and interpretation of DBS treatment effects and side effects.
