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Cytochromes p450: roles in diseases
Irina A Pikuleva1, Michael R Waterman
1Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio 44106, USA. iap8@case.edu
The Journal of Biological Chemistry
|May 2, 2013
Summary
Cytochrome P450 enzymes are crucial for drug metabolism and synthesizing essential bodily compounds. This review details medically significant human P450s and their associated diseases.
Area of Science:
- Biochemistry
- Pharmacology
- Human Physiology
Background:
- The cytochrome P450 (P450) superfamily comprises numerous heme-containing monooxygenases vital for biological processes.
- Many human P450 enzymes are involved in metabolizing therapeutic drugs and synthesizing endogenous compounds.
- Dysregulation of specific P450s can lead to various human diseases.
Purpose of the Study:
- To review medically significant human P450 enzymes.
- To associate specific P450 families with human diseases.
Main Methods:
- Literature review of human P450 enzymes.
- Focus on P450 families 2, 4, 7, 11, 17, 19, 21, 24, 27, 46, and 51.
Main Results:
- Identification of key human P450s involved in drug metabolism.
- Identification of key human P450s involved in endogenous compound synthesis.
- Correlation of altered P450 function with specific disease states.
Conclusions:
- Human P450 enzymes play critical roles in health and disease.
- Understanding P450s and associated diseases is essential for therapeutic development.
- This review provides a comprehensive overview of medically relevant P450s and their disease associations.
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01:31Translation
Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
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