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Updated: May 11, 2026

Pull-down of Calmodulin-binding Proteins
Published on: January 23, 2012
Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II
Margaret M Stratton1, Luke H Chao, Howard Schulman
1Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
Abstract:
Ca(2+)/calmodulin dependent protein kinase II (CaMKII) is a broadly distributed metazoan Ser/Thr protein kinase that is important in neuronal and cardiac signaling. CaMKII forms oligomeric assemblies, typically dodecameric, in which the calcium-responsive kinase domains are organized around a central hub. We review the results of crystallographic analyses of CaMKII, including the recently determined structure of a full-length and autoinhibited form of the holoenzyme. These structures, when combined with other data, allow informed speculation about how CaMKII escapes calcium-dependence when calcium spikes exceed threshold frequencies.
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