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Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

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Related Experiment Video

Updated: May 11, 2026

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform
06:27

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

Published on: October 20, 2020

Polyurethane-based drug delivery systems.

Jong Yuh Cherng1, Ting Yi Hou, Mei Fen Shih

  • 1Department of Chemistry and Biochemistry, National Chung Cheng University, 168 University Rd., Chia-Yi, Taiwan. chejyc@ccu.edu.tw

International Journal of Pharmaceutics
|May 2, 2013
PubMed
Summary
This summary is machine-generated.

Polyurethanes (PUs) are versatile polymers synthesized from isocyanates and diols. This review covers PU synthesis, characterization, biodegradability, and their applications in drug delivery and biotherapeutics.

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Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Drug Delivery Systems

Background:

  • Polyurethanes (PUs) are polymers characterized by urethane linkages, formed via the reaction of isocyanates and diols.
  • A wide array of commercially available building blocks enables tailoring of PU properties for specific applications.
  • PUs are increasingly utilized in biomedical and pharmaceutical fields due to their tunable characteristics.

Purpose of the Study:

  • To review the synthesis and characterization of polyurethanes and their copolymers.
  • To examine the in vitro and in vivo biodegradability and biocompatibility of PUs.
  • To highlight the application of PUs in controlled drug release and targeted biotherapeutic delivery.

Main Methods:

  • Literature review of scientific publications on polyurethane synthesis and characterization.
  • Analysis of studies reporting in vitro and in vivo degradation profiles of PUs.
  • Evaluation of research on the use of PUs for drug and biotherapeutic delivery systems.

Main Results:

  • Polyurethanes offer versatile synthetic routes and tunable properties through diverse building blocks.
  • PUs exhibit varying degrees of biodegradability and biocompatibility, suitable for biomedical applications.
  • Significant potential exists for PUs in advanced drug delivery, including controlled and targeted release.

Conclusions:

  • Polyurethanes are highly adaptable polymers with significant promise in biomedical and pharmaceutical applications.
  • Further research into PU biodegradability and biocompatibility will enhance their clinical translation.
  • PUs are effective platforms for developing next-generation controlled drug release and targeted biotherapeutic delivery systems.