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Updated: May 11, 2026

Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging

Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging

Published on: February 7, 2014

Pulse wave velocity and cognitive function in older adults.

Wenjun Zhong¹, Karen J Cruickshanks, Carla R Schubert

¹Department of Population Health Sciences, University of Wisconsin-Madison, WI.

Alzheimer Disease and Associated Disorders

|May 2, 2013

Summary

Increased arterial stiffness, measured by carotid-femoral pulse wave velocity (CF-PWV), is linked to poorer cognitive function in older adults. This highlights a potential connection between vascular health and brain health.

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Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness

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Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness

Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness

Published on: May 3, 2018

Area of Science:

Cardiovascular Health
Neuroscience
Gerontology

Background:

Arterial stiffness is an emerging risk factor for cognitive decline.
Understanding the relationship between large artery stiffness and cognitive performance is crucial for aging populations.

Purpose of the Study:

To investigate the association between arterial stiffness, specifically carotid-femoral pulse wave velocity (CF-PWV) and carotid-radial pulse wave velocity (CR-PWV), and cognitive function in a large cohort.

Main Methods:

1433 participants (mean age 75) underwent CF-PWV and CR-PWV measurements.
Cognitive function was assessed using six tests covering executive function, memory, and processing speed.
Statistical analyses adjusted for multiple potential confounders.

Main Results:

Higher CF-PWV (stiffness) was significantly associated with lower scores on the Mini-Mental State Examination and Auditory Verbal Learning Test.
Increased CF-PWV also correlated with a lower composite cognition score and marginally with slower performance on Trail Making Test-part B.
No significant associations were observed between CR-PWV and cognitive measures.

Conclusions:

Elevated large artery stiffness, indicated by CF-PWV, is associated with impaired cognitive function in older adults.
Further longitudinal research is warranted to establish causality and explore potential interventions.