Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
Social Anxiety Disorder01:28

Social Anxiety Disorder

Social anxiety disorder, also known as social phobia, is characterized by an intense fear of social situations where one might face humiliation, rejection, embarrassment, or negative evaluation. This disorder leads individuals to avoid activities like casual conversations, public speaking, or seemingly simple tasks such as eating, signing documents, or swimming, in public settings. Its impact extends beyond discomfort, often significantly interfering with daily functioning and quality of life.
Sex-linked Disorders01:43

Sex-linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
Lethal Alleles02:41

Lethal Alleles

Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Esophageal Achalasia01:27

Esophageal Achalasia

Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...
Genetic Lingo01:11

Genetic Lingo

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human genomics of the humoral immune response against polyomaviruses.

Virus evolution·2021
Same author

The Summer School Oncology Groningen: Improving a Successful International Course by Refining the Old, Maintaining What's Good.

Journal of cancer education : the official journal of the American Association for Cancer Education·2021
Same author

[Church register entry on the death of Albinus in translation-for a better understanding].

Der Anaesthesist·2020
Same author

<i>Ex situ</i> management of Beira antelope <i>Dorcatragus megalotis</i> at Al Wabra Wildlife Preservation, Qatar.

The International zoo yearbook·2020
Same author

A propensity-matched study of full laparoscopic versus hand-assisted minimal-invasive liver surgery.

Surgical endoscopy·2020
Same author

[Erratum to: Management of patients with chronic pain in acute and perioperativemedicine : An interdisciplinary challenge].

Der Anaesthesist·2020
Same journal

Immune-metabolic mediation of depression risk: Causal evidence from antibody and metabolite GWAS.

Translational psychiatry·2026
Same journal

DRD1 and DRD2 dopamine-sensitive neurons in the central amygdala respond differently to rewarding and aversive stimuli.

Translational psychiatry·2026
Same journal

Neuroinflammation and depression: immune-brain interface mechanisms, biomarker stratification, and therapeutic strategies.

Translational psychiatry·2026
Same journal

Operationalization drift in the construct of impulsivity: relevance to animal models of addiction.

Translational psychiatry·2026
Same journal

Kappa-opioid receptor activation promotes depression-like behaviors by suppressing Pax6-dependent adult hippocampal neurogenesis.

Translational psychiatry·2026
Same journal

Imbalance in excitation and inhibition in sgACC is associated with depression in dementia with Lewy bodies.

Translational psychiatry·2026
See all related articles

Related Experiment Video

Updated: May 11, 2026

Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders
06:30

Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders

Published on: June 13, 2015

A single gene defect causing claustrophobia.

A El-Kordi1, A Kästner, S Grube

  • 1Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany.

Translational Psychiatry
|May 2, 2013
PubMed
Summary
This summary is machine-generated.

Genetic mutations in the GPM6A gene can cause claustrophobia, a fear of enclosed spaces. Stress disrupts the regulation of this gene, increasing genetic risk for the condition.

More Related Videos

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

Related Experiment Videos

Last Updated: May 11, 2026

Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders
06:30

Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders

Published on: June 13, 2015

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Claustrophobia is commonly viewed as a learned fear response.
  • The genetic underpinnings and neurobiological mechanisms remain incompletely understood.

Purpose of the Study:

  • To investigate the potential genetic basis of claustrophobia.
  • To explore the role of the GPM6A gene in the development of claustrophobia.

Main Methods:

  • Analysis of Gpm6a-deficient mice under stress conditions.
  • Genetic sequencing of the GPM6A gene in human subjects.
  • Investigation of gene regulation by microRNA (miR124).

Main Results:

  • Gpm6a-deficient mice exhibited a claustrophobia-like phenotype upon mild stress.
  • Nine GPM6A gene variants were found to be more frequent in claustrophobic individuals.
  • A specific GPM6A 3'UTR variant impaired repression by miR124.

Conclusions:

  • Mutations in the GPM6A gene represent a genetic risk factor for claustrophobia.
  • Dysregulation of neuronal GPM6A expression, particularly under stress, contributes to claustrophobia.
  • This study identifies a novel genetic pathway implicated in the etiology of claustrophobia.