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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

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Related Experiment Video

Updated: May 11, 2026

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death
07:08

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death

Published on: June 6, 2025

Donation after circulatory death: current status.

Arne Neyrinck1, Dirk Van Raemdonck, Diethard Monbaliu

  • 1Division of Anesthesiology and Algology, University Hospitals Leuven, Leuven, Belgium. arne.neyrinck@uzleuven.be

Current Opinion in Anaesthesiology
|May 2, 2013
PubMed
Summary
This summary is machine-generated.

Donation after circulatory death (DCD) offers a valuable option to expand the donor pool, with acceptable outcomes for kidney and lung transplants. Further research is needed to optimize DCD graft quality and establish uniform guidelines.

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Pre-clinical Model of Cardiac Donation after Circulatory Death
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Pre-clinical Model of Cardiac Donation after Circulatory Death

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Last Updated: May 11, 2026

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Area of Science:

  • Transplantation Medicine
  • Organ Donation Research

Background:

  • Critical donor shortages necessitate innovative strategies to expand the organ donor pool.
  • Donation after circulatory death (DCD) presents a promising avenue to augment the availability of organs for transplantation.

Purpose of the Study:

  • To review current practices in DCD donation.
  • To identify unresolved ethical and medical questions in DCD transplantation.

Main Methods:

  • Literature review of recent findings and clinical practices in DCD.
  • Analysis of outcomes and emerging preservation techniques.

Main Results:

  • DCD transplantation shows acceptable outcomes for kidney and lung, but inferior graft survival for liver.
  • The agonal phase in controlled DCD is increasingly recognized; premortem interventions and advanced preservation strategies (e.g., machine perfusion) are under investigation.
  • More uniform guidelines for DCD organ procurement are being reported.

Conclusions:

  • DCD donation is now standard practice but not a direct substitute for donation after brain death.
  • Continued exploration of DCD potential, long-term outcome monitoring, and graft quality optimization are crucial.
  • Standardized guidelines are essential for the widespread clinical application of DCD organs.