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Metabolic and hormonal consequences of two different meals after a moderate intensity exercise bout in obese
C Maffeis1, R Bonadonna, M Maschio
1Department of Life and Reproduction Sciences, University of Verona, Verona, Italy. claudio.maffeis@univr.it
Insights
A high-fat/low-carbohydrate meal negatively impacts nutrient balance and energy metabolism post-exercise compared to a low-fat/high-carbohydrate meal in obese children.
Area of Science:
- Pediatric Obesity Research
- Nutritional Science
- Exercise Physiology
Background:
- Understanding postprandial metabolic responses is crucial for managing pediatric obesity.
- Exercise influences nutrient utilization and hormonal regulation.
Purpose of the Study:
- To compare the effects of high-fat/low-carbohydrate versus low-fat/high-carbohydrate meals on nutrient balance, hormones, and appetite in prepubertal obese children after exercise.
- To investigate the relationship between postprandial nutrient balance, satiety, and hormone changes.
Main Methods:
- Cross-over study with 10 prepubertal obese children.
- Isocaloric meals (low-fat/high-carb vs. high-fat/low-carb) consumed after 30-min moderate-intensity exercise.
- Measured substrate oxidation, biochemical parameters, gastrointestinal hormones, and appetite for 5 hours post-meal.
Main Results:
- The high-fat/low-carb meal resulted in a higher fat balance and lower carbohydrate balance.
- Elevated energy balance and plasma triglyceride concentrations were observed after the high-fat/low-carb meal.
- Significantly higher serum glucagon-like peptide-1 concentrations were noted post high-fat/low-carb meal.
Conclusions:
- A high-fat/low-carbohydrate meal has a less favorable metabolic impact compared to an isoenergetic, isoproteic low-fat/high-carbohydrate meal after exercise.
- Dietary fat content significantly influences postprandial metabolism and hormonal responses in obese children.
Background/Objectives:
To investigate the relationship between postprandial nutrient balance, satiety and hormone changes induced by two different meals taken after a moderate intensity exercise bout.
Subjects/Methods:
Ten prepubertal obese children participated in the study. The experiment was designed as a cross-over study for repeated measures. Each test period lasted five consecutive hours during which the children were under medical supervision. The effects of two isocaloric meals were compared after a moderate intensity exercise (4 multiples of resting metabolic rate, 30 min, cycling): a low-fat/high-carbohydrate meal (meal A) and a high-fat/low-carbohydrate meal (meal B). Pre and postprandial (3 h) substrate oxidation, biochemical parameters, gastrointestinal hormone concentrations and appetite were measured.
Results:
The main results were: (i) higher fat balance (5.1±5.0 vs -5.0±6.6 g, P=0.001) and lower carbohydrate balance after meal B than A (-9.7±13.3 vs 11.3±18.3 g, P<0.01); (ii) higher energy balance after meal B than after meal A (5.9±21.5 vs -13.9±20.2 kcal, P<0.05); (iii) higher plasma triglyceride concentrations (area under the curve) after meal B than after meal A (2962.5±2095.8 mg*180 min/dl vs -169.5±1633.7 mg*180 min/dl, P<0.01); (iv) higher serum glucagon-like peptide-1 concentrations after meal B than after meal A (1101.5±873.0 pmol*180 min/l vs 478.8±638.3 pmol*180 min/l, P<0.05).
Conclusions:
After a bout of moderate intensity exercise, a meal with a high-fat/low-carbohydrate ratio had a less favorable metabolic impact than an isoenergetic, isoproteic low-fat/high-carbohydrate meal.
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