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Related Experiment Videos

Pneumococcal antigen in lobar pneumonia.

P Tugwell, B M Greenwood

    Journal of Clinical Pathology
    |February 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Detecting pneumococcal antigen in patients with lobar pneumonia aids diagnosis and reveals clinical implications. This antigen detection is valuable even after antibiotic treatment and correlates with increased patient complications.

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    Area of Science:

    • Medical Microbiology
    • Infectious Diseases
    • Clinical Diagnostics

    Background:

    • Lobar pneumonia remains a significant cause of morbidity and mortality.
    • Accurate and timely diagnosis of bacterial pneumonia is crucial for effective treatment.
    • Strengthening diagnostic methods for pneumococcal pneumonia is an ongoing clinical need.

    Purpose of the Study:

    • To evaluate the diagnostic utility of detecting pneumococcal antigen in patients with lobar pneumonia.
    • To explore the clinical implications of pneumococcal antigen detection, including associated complications.
    • To assess the impact of prior antibiotic therapy on antigen detection.

    Main Methods:

    • Investigated 98 patients diagnosed with lobar pneumonia.
    • Employed counter-current immunoelectrophoresis (CIE) for pneumococcal antigen detection.

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  • Analyzed antigen presence in sputum, serum, and urine samples.

    • Main Results:

    • Pneumococcal antigen was detected in 79% of purulent sputum, 29% of serum, and 54% of urine samples.
    • Diagnostic value of CIE was unaffected by previous antibiotic administration.
    • Antigenaemia (presence of antigen in serum) was associated with higher complication rates (jaundice, diarrhea, persistent fever).
    • Circulating antigen persisted for at least seven days in 50% of patients, suggesting potential immunological tolerance.

    Conclusions:

    • Detection of pneumococcal antigen via CIE is a valuable diagnostic tool for lobar pneumonia.
    • Antigenaemia serves as an indicator of increased risk for severe clinical complications.
    • The persistence of antigen may imply the development of immunological tolerance in some patients.