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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Related Experiment Video

Updated: May 11, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

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Published on: March 12, 2016

Interventions for improving adherence to ocular hypotensive therapy.

Heather Waterman1, Jennifer R Evans, Trish A Gray

  • 1School of Nursing, Midwifery and Social Work, University of Manchester, Manchester, UK. heather.waterman@manchester.ac.uk.

The Cochrane Database of Systematic Reviews
|May 2, 2013
PubMed
Summary
This summary is machine-generated.

Improving adherence to glaucoma medication is crucial. Complex interventions, including patient education and personalized support, show promise, but more research is needed to confirm effectiveness and identify optimal strategies for ocular hypotensive therapy.

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Last Updated: May 11, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Area of Science:

  • Ophthalmology
  • Pharmacology
  • Health Services Research

Background:

  • Poor adherence to ocular hypotensive therapy is a significant issue in managing chronic conditions like open-angle glaucoma.
  • Treatment failure due to non-adherence can lead to increased healthcare costs and necessitate surgical intervention.

Purpose of the Study:

  • To systematically review the effectiveness of interventions aimed at improving patient adherence to ocular hypotensive therapy for glaucoma and ocular hypertension.

Main Methods:

  • Conducted a comprehensive literature search across multiple databases for randomized controlled trials (RCTs) and quasi-RCTs.
  • Included studies comparing interventions to improve adherence to ocular hypotensive therapy.
  • Assessed study quality and extracted data independently, noting heterogeneity prevented data pooling.

Main Results:

  • Sixteen trials involving 1565 participants were included, focusing on patient education, different drug regimens, and reminder devices.
  • Variable study quality and short follow-up periods (mostly <6 months) limited definitive conclusions.
  • Some evidence suggests that complex interventions combining education with personalized behavioral changes may improve adherence, but results were not conclusive for simplified regimens or reminder devices.

Conclusions:

  • Complex interventions involving patient education and personalized behavioral support show potential for improving glaucoma medication adherence.
  • Insufficient evidence exists to recommend a specific intervention due to study heterogeneity and lack of standardized outcomes.
  • Future research should include longer follow-up periods (≥1 year) and standardized outcome measures, including cost-effectiveness.