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Updated: May 11, 2026

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome
03:40

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome

Published on: April 25, 2025

Interventions for acute internal hordeolum.

Kristina Lindsley1, Jason J Nichols, Kay Dickersin

  • 1Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. klindsle@jhsph.edu.

The Cochrane Database of Systematic Reviews
|May 2, 2013
PubMed
Summary
This summary is machine-generated.

No studies support or refute nonsurgical treatments for acute internal hordeolum. More clinical trials are needed to determine effective interventions for this common eyelid inflammation.

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Surgical Correction for Pediatric Epiblepharon and Trichiasis
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Published on: July 8, 2025

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Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome
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Published on: April 25, 2025

Surgical Correction for Pediatric Epiblepharon and Trichiasis
03:59

Surgical Correction for Pediatric Epiblepharon and Trichiasis

Published on: July 8, 2025

Area of Science:

  • Ophthalmology
  • Evidence-Based Medicine

Background:

  • Hordeolum is a common, painful bacterial eyelid inflammation affecting oil glands.
  • It can be internal or external, with spontaneous resolution common but recurrences possible.
  • Acute internal hordeolum may progress to chronic forms or chalazion if untreated.

Purpose of the Study:

  • To evaluate the efficacy and safety of nonsurgical treatments for acute internal hordeolum.
  • To compare these treatments against observation or placebo.

Main Methods:

  • Systematic review of randomized or quasi-randomized clinical trials.
  • Searched multiple databases including CENTRAL, MEDLINE, EMBASE, LILACS, mRCT, ClinicalTrials.gov, and WHO ICTRP.
  • Included studies focused on acute internal hordeolum and excluded external hordeolum, chronic hordeolum, or chalazion.

Main Results:

  • No clinical trials met the inclusion criteria for this review.
  • Identified references primarily discussed external hordeola, chronic conditions, or were observational studies/case reports.
  • No data was found on nonsurgical interventions for acute internal hordeolum.

Conclusions:

  • There is a lack of evidence regarding the effectiveness of nonsurgical treatments for hordeolum.
  • Further controlled clinical trials are essential to identify effective interventions for acute internal hordeolum.