[Oral cyclosporine pharmacokinetics in renal transplantation patients]

Cyclosporine was extracted from whole blood and analyzed by HPLC. The pharmacokinetics of oral cyclosporine were studied in patients with renal transplant. They were 5 women and 3 men between the ages of 29-49 years. Cyclosporine was used for 47 days to 11 months after renal transplantation. The mean dose was 8.26 +/- 1.41 mg/kg.d (5.88-10.0 mg/kg.d), once each 12 hours. Three hundreds whole blood samples were monitored. The peak concentration (Cmax) was 664.9 +/- 87.5 ng/ml; peak time was 3.27 +/- 1.07 h; slow elimination phase t1/2 beta was 13.53 (6.13-43.3) h.