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Related Experiment Video

Updated: May 11, 2026

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

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Altered resting-state brain activity in obstructive sleep apnea.

Quan Zhang¹, Dawei Wang, Wen Qin

¹Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China.

|May 2, 2013

Summary

Obstructive sleep apnea (OSA) alters brain connectivity and structure, particularly in cognitive and sensorimotor networks. These changes correlate with OSA severity, impacting brain function.

Keywords:

Brain networks functional connectivity independent component analysis obstructive sleep apnea voxel-based morphometry

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Published on: December 22, 2016

Area of Science:

Neuroimaging
Sleep Medicine
Neurology

Background:

Obstructive sleep apnea (OSA) is linked to neural dysfunction.
The impact of OSA on resting-state brain activity remains unclear.

Purpose of the Study:

Investigate resting-state functional connectivity (rsFC) alterations in brain networks in OSA patients.
Examine relationships between rsFC changes and gray matter volume (GMV) in corresponding brain regions.

Main Methods:

Acquired resting-state functional and structural MRI data from 24 male OSA patients and 21 controls.
Utilized independent component analysis to identify seven brain networks.
Compared rsFC and GMV between groups.

Main Results:

OSA affected cognitive and sensorimotor networks, not visual/auditory.
Decreased rsFC and GMV observed in medial prefrontal cortex and left DLPFC.
Decreased rsFC with unchanged GMV in right DLPFC and left precentral gyrus.
Increased rsFC with unchanged GMV in right posterior cingulate cortex.
Right DLPFC rsFC negatively correlated with apnea-hypopnea index in OSA patients.

Conclusions:

OSA specifically impacts rsFC in cognitive and sensorimotor networks.
Observed brain changes may underlie impaired cognitive and motor functions in OSA.