Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
Mitochondrial Membranes01:45

Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
Mitochondrial Membranes01:45

Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
Peroxisomes and Mitochondria01:30

Peroxisomes and Mitochondria

Peroxisomes and mitochondria are two important oxygen-utilizing organelles in eukaryotic cells. Mitochondria carry out cellular respiration—the process that converts energy from food into ATP. Peroxisomes carry out a variety of functions, primarily breaking down different substances, such as fatty acids.
The peroxisome is a single membrane-bound cellular organelle that can perform several different functions, including lipid metabolism and chemical detoxification. The enzymes within peroxisomes...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ageing stress signalling: metastatic plasticity and metabolic vulnerability in lung cancer.

Signal transduction and targeted therapy·2026
Same author

Retraction Note: Effects of innate immune receptor stimulation on extracellular α-synuclein uptake and degradation by brain resident cells.

Experimental & molecular medicine·2026
Same author

Detection of atrial fibrillation via adhesive single-lead ECG vs. Holter monitoring in embolic stroke of undetermined source: the AVANT-GARDE trial.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2026
Same author

Therapeutic Effects of Fermented Soy Extract on Osteoporotic Changes in Ovariectomized Mice as a Model of Menopause.

Molecular nutrition & food research·2026
Same author

Angelic Acid Disassembles Fibrillar α-Synuclein Aggregates through β-Sheet Interface Disruption.

ACS chemical neuroscience·2026
Same author

Ethyl acetate extract of Lactococcus lactis KR-050L suppresses IL-6/STAT3 signaling in Hep3B cells and alleviates DSS-induced colitis in mice.

Journal of biotechnology·2026

Related Experiment Video

Updated: May 11, 2026

Imaging of mtHyPer7, a Ratiometric Biosensor for Mitochondrial Peroxide, in Living Yeast Cells
09:47

Imaging of mtHyPer7, a Ratiometric Biosensor for Mitochondrial Peroxide, in Living Yeast Cells

Published on: June 2, 2023

Mitochondria and organismal longevity.

Ara B Hwang1, Dae-Eun Jeong, Seung-Jae Lee

  • 1Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang, Kyungbuk, South Korea.

Current Genomics
|May 2, 2013
PubMed
Summary

Mitochondria, crucial for energy, paradoxically extend lifespan when their function is mildly inhibited. This review explores how mitochondrial roles in aging connect to longevity pathways like dietary restriction.

Keywords:
AgingDietary restrictionMitochondriaReactive oxygen speciesTarget of rapamycin (TOR).

More Related Videos

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans
07:25

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans

Published on: December 9, 2022

Related Experiment Videos

Last Updated: May 11, 2026

Imaging of mtHyPer7, a Ratiometric Biosensor for Mitochondrial Peroxide, in Living Yeast Cells
09:47

Imaging of mtHyPer7, a Ratiometric Biosensor for Mitochondrial Peroxide, in Living Yeast Cells

Published on: June 2, 2023

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans
07:25

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans

Published on: December 9, 2022

Area of Science:

  • Cellular Biology
  • Aging Research
  • Mitochondrial Biology

Background:

  • Mitochondria are vital for cellular energy production.
  • The oxidative stress theory links mitochondrial reactive oxygen species (ROS) to aging.
  • Contradictory findings suggest ROS or inhibited mitochondrial function may delay aging.

Purpose of the Study:

  • To review current research on mitochondria's role in organismal aging.
  • To explore how mitochondria influence longevity pathways.

Main Methods:

  • Literature review of recent scientific findings.
  • Analysis of studies on mitochondrial function and aging.
  • Discussion of conserved longevity pathways.

Main Results:

  • Mitochondria's role in aging is complex and not solely detrimental.
  • Increased ROS or inhibited mitochondrial function can promote longevity.
  • Mitochondria are implicated in pathways like dietary restriction and TOR signaling.

Conclusions:

  • Mitochondria are central to aging processes, with implications for lifespan.
  • Understanding mitochondrial regulation offers potential therapeutic targets for aging.