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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
5-Iodo-3-phenyl-2,1-benzoxazole
Yuriy Teslenko1, Vasyl S Matiychuk, Vasyl Kinzhybalo
1Department of Organic Chemistry, Ivan Franko National University of Lviv, Kyryla and Mefodiya 6, Lviv 79005, Ukraine.
Researchers synthesized a novel C13H8INO compound using a condensation reaction. Crystal analysis revealed specific molecular arrangements and intermolecular interactions influencing its structure.
Area of Science:
- Organic Chemistry
- Crystallography
Background:
- Benzoisoxazole derivatives are important in medicinal chemistry.
- Understanding the synthesis and structural properties of novel organic compounds is crucial.
Purpose of the Study:
- To synthesize and characterize a new organic compound with the formula C13H8INO.
- To investigate the crystal structure and intermolecular interactions of the synthesized compound.
Main Methods:
- Condensation reaction between 4-nitro-benzene and phenyl-acetonitrile.
- X-ray crystallography for structural determination.
Main Results:
- Successful synthesis of the title compound C13H8INO.
- Identification of two independent molecules in the asymmetric unit.
- Quantification of dihedral angles between the benzene ring and benzoisoxazole unit (4.2(3)° and 4.1(3)°).
- Analysis of crystal packing governed by C-H⋯N, C-I⋯π, and C-I⋯O interactions.
Conclusions:
- The study reports the synthesis and detailed crystal structure of a novel C13H8INO compound.
- The findings provide insights into the structural features and intermolecular forces governing the crystal packing of this class of compounds.
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