Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Benzene to 1,4-Cyclohexadiene: Birch Reduction Mechanism

Benzene to 1,4-Cyclohexadiene: Birch Reduction Mechanism

Birch reduction uses solvated electrons as reducing agents. The reaction converts benzene to 1,4-cyclohexadiene. The reaction proceeds by the transfer of a single electron to the ring to form a benzene radical anion. This anion is highly basic—it abstracts a proton from the alcohol to form a cyclohexadienyl radical. Another single electron transfer gives the cyclohexadienyl anion. A proton transfer from the alcohol forms 1,4-cyclohexadiene. Since this reduction occurs via radical anion...

Nucleophilic Aromatic Substitution: Elimination–Addition

Nucleophilic Aromatic Substitution: Elimination–Addition

Simple aryl halides do not react with nucleophiles. However, nucleophilic aromatic substitutions can be forced under certain conditions, such as high temperatures or strong bases. The mechanism of substitution under such conditions involves the highly unstable and reactive benzyne intermediate. Benzyne contains equivalent carbon centers at both ends of the triple bond, each of which is equally susceptible to nucleophilic attack. This 50–50 distribution of products is confirmed through isotopic...

Anthelminthic Agents

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Intramolecular NMe<sub>2</sub>H Elimination and Fulvene Coupling Leading to Novel Allyl-Bridged Zirconocene and Hafnocene Complexes.

Angewandte Chemie (International ed. in English)·2021

Same author

Crystal structure of bis-(N-tert-butyl-benzamidinium) hexa-chlorido-zirconate(IV) di-chloro-methane disolvate.

Acta crystallographica. Section E, Crystallographic communications·2016

Same author

Coordination reactions of 2-pyridinecarboxaldehyde-phenylhydrazonatolithium with selected transition metal (Zn, Sn, Fe, Co, Ni and Zr) chlorides and its coupling reaction with dichloromethane.

Dalton transactions (Cambridge, England : 2003)·2016

Same author

Discovery and synthesis of cyclohexenyl derivatives as modulators of CC chemokine receptor 2 activity.

Bioorganic & medicinal chemistry letters·2015

Same author

Crystal structure of N'-(2,6-di-methyl-phen-yl)benzene-carboximidamide tetra-hydro-furan monosolvate.

Acta crystallographica. Section E, Crystallographic communications·2015

Same author

Tetra-chlorido-[N (2),N (2')-(di-methyl-silanedi-yl)bis-(N-tert-butyl-3-methyl-benzimid-amid-ato)-κ(2) N (2),N (2')]hafnium(IV).

Acta crystallographica. Section E, Structure reports online·2014

Search research articles

Related Experiment Video

Updated: May 11, 2026

Methods to Inhibit Bacterial Pyomelanin Production and Determine the Corresponding Increase in Sensitivity to Oxidative Stress

Methods to Inhibit Bacterial Pyomelanin Production and Determine the Corresponding Increase in Sensitivity to Oxidative Stress

Published on: August 31, 2015

N-Cyclo-hexyl-3-methyl-benzamidine.

Rui-Qin Liu¹, Sheng-Di Bai, Tao Wang

¹Institute of Applied Chemistry, Shanxi University, Taiyuan 030006, People's Republic of China.

Acta Crystallographica. Section E, Structure Reports Online

|May 2, 2013

Summary

This study details the synthesis and structural analysis of an asymmetric amidine compound (C14H20N2). The research reveals its unique molecular arrangement and intermolecular hydrogen bonding in crystal form.

Area of Science:

Organic Chemistry
Crystallography

Background:

Amidine compounds are versatile organic molecules with diverse applications.
Understanding the structure-property relationships of amidines is crucial for their development.

Purpose of the Study:

To synthesize and characterize a novel asymmetric amidine compound.
To elucidate the molecular structure and crystal packing of the synthesized compound.

Main Methods:

One-pot synthesis reaction.
Single-crystal X-ray diffraction analysis.
Analysis of molecular conformation and hydrogen bonding.

Main Results:

Successfully synthesized the asymmetric amidine C14H20N2 via a one-pot reaction.

More Related Videos

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase

Published on: November 23, 2016

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions

Published on: July 30, 2017

Related Experiment Videos

Last Updated: May 11, 2026

Methods to Inhibit Bacterial Pyomelanin Production and Determine the Corresponding Increase in Sensitivity to Oxidative Stress

Methods to Inhibit Bacterial Pyomelanin Production and Determine the Corresponding Increase in Sensitivity to Oxidative Stress

Published on: August 31, 2015

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase

Published on: November 23, 2016

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions

Published on: July 30, 2017

Determined the crystal structure, revealing a chair conformation of the cyclohexyl group and a dihedral angle of 47.87° between the phenyl ring and NCN plane.

Identified N-H⋯N hydrogen bonds facilitating the formation of chains along the a-axis in the crystal.

Conclusions:

The synthesized amidine exhibits asymmetry due to differential N-alkylation.
The crystal structure provides insights into the conformational preferences and intermolecular interactions of this class of compounds.