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High-speed separations of DNA sequencing reactions by capillary electrophoresis
H Drossman1, J A Luckey, A J Kostichka
1Department of Chemistry, University of Wisconsin, Madison 53706.
Analytical Chemistry
|May 1, 1990
Abstract:
Fluorescently labeled DNA fragments generated in enzymatic sequencing reactions are rapidly separated by capillary gel electrophoresis and detected at attomole levels within the gel-filled capillary. The application of this technology to automated DNA sequence analysis may permit the development of a second generation automated sequencer capable of efficient and cost-effective sequence analysis on the genomic scale.