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Advancing Dyslexia Assessment in Children Through Computerized Testing

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Published on: August 16, 2024

Subject-centered free-response ROC (FROC) analysis.

Andriy I Bandos¹, Howard E Rockette, David Gur

¹Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, Pennsylvania 15261, USA. anb61@pitt.edu

Medical Physics

|May 3, 2013

Summary

A new subject-centered free-response receiver operating characteristic (FROC) curve approach offers patient-centered insights into diagnostic system performance, revealing potential limitations of conventional target-centered methods, especially when target numbers vary.

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Area of Science:

Medical Imaging Analysis
Diagnostic Performance Evaluation
Receiver Operating Characteristic (ROC) Analysis

Background:

Conventional target-centered free-response receiver operating characteristic (FROC) curves may offer inadequate patient-centered inferences.
Diagnostic performance can correlate with the total number of targets per subject, impacting traditional FROC analysis.

Purpose of the Study:

To develop a subject-centered FROC curve estimation approach.
To provide patient-centered inferences on diagnostic system detection-localization characteristics.

Main Methods:

Examined properties of conventional target-centered FROC curves.
Defined and formulated a subject-centered FROC curve as a covariate-adjusted FROC curve.
Conducted a numerical study comparing conventional and subject-centered approaches.

Main Results:

Developed a simple, implementable approach for estimating the subject-centered FROC curve and its index.
Demonstrated that a system superior by target-centered metrics can be inferior from a subject-centered perspective.
Showed that disagreements between methods can be substantial under clinically reasonable conditions.

Conclusions:

The developed subject-centered FROC curve and its index offer tools for patient-centered inferences.
This approach provides relevant insights into potential patient benefits from diagnostic systems.
Findings can contradict conclusions from conventional target-centered FROC analysis.