Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 11, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

A novel dose-based positioning method for CT image-guided proton therapy.

Joey P Cheung1, Peter C Park, Laurence E Court

  • 1Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 94, Houston, Texas 77030, USA.

Medical Physics
|May 3, 2013
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

RADIANT: A fully configurable radiotherapy dose prediction framework.

Biomedical physics & engineering express·2026
Same author

Defining a Quantitative Threshold for Adaptive Re-planning using a Percentile-based Scoring System.

International journal of particle therapy·2026
Same author

Novel pencil-beam scanning proton lattice radiation therapy for the treatment of bulky liver cancer: dosimetric comparison with VMAT-lattice radiotherapy.

Frontiers in oncology·2026
Same author

Leveraging large language models for heuristic usability assessment of medical software: Insights with the Radiation Planning Assistant.

Journal of applied clinical medical physics·2026
Same author

Novel volumetric modulated arc therapy approach for lattice radiation therapy for bulky liver tumors.

Frontiers in oncology·2025
Same author

Intentional creation of suboptimal, realistic dose distributions.

Journal of applied clinical medical physics·2025
Same journal

Correction to "On the shape of the radiation survival curve in tumor spheroids: The role of oxygen heterogeneity".

Medical physics·2026
Same journal

Multi-view constrained semi-supervised vertebra detection for 3D ultrasound spine volume.

Medical physics·2026
Same journal

Accuracy of quantitative <sup>177</sup>Lu SPECT/CT imaging: A systematic review.

Medical physics·2026
Same journal

Physics-constrained dual-domain network for CBCT reconstruction from orthogonal X-rays in gynecologic radiotherapy.

Medical physics·2026
Same journal

Decomposition-based harmonization for quantitative PET imaging across scanners and radiotracers.

Medical physics·2026
Same journal

Development and evaluation of an in vivo dose-based monitoring system for electron FLASH radiation therapy.

Medical physics·2026
See all related articles

This study shows that using dose-based alignment, instead of just anatomy, improves proton therapy accuracy for lung cancer patients. All patients met target coverage, and normal tissue sparing was enhanced.

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Image-Guided Therapy

Background:

  • Anatomical changes can alter proton dose distributions during therapy.
  • Traditional image guidance relies on anatomy, potentially leading to suboptimal target alignment.

Purpose of the Study:

  • To explore using dosimetric factors for patient setup in proton therapy.
  • To improve target coverage and normal tissue sparing using dose-based isocenter shifts.

Main Methods:

  • Simulated patient anatomy using 4D CT data from 15 lung cancer patients.
  • Implemented a dose-based isocenter shift method correcting dosimetric deviations without replanning.
  • Optimized alignment by ensuring target coverage and minimizing dose to the ipsilateral lung.

More Related Videos

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

Related Experiment Videos

Last Updated: May 11, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

Main Results:

  • Anatomy-based alignment failed target coverage in 7 of 15 plans.
  • Dose-based alignment ensured all plans met target coverage constraints.
  • Dose-based alignment improved normal tissue sparing in most cases.

Conclusions:

  • Dose-based isocenter adjustment enhances target coverage in proton therapy.
  • This method can effectively reduce radiation dose to surrounding normal tissues.