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Updated: May 11, 2026

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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ALBIRA: a small animal PET∕SPECT∕CT imaging system.

F Sánchez1, A Orero, A Soriano

  • 1Instituto de Instrumentación para Imagen Molecular (I3M), Centro mixto CSIC - Universitat Politècnica de València - CIEMAT, camino de Vera s∕n, 46022 Valencia, Spain. filsan@i3m.upv.es

Medical Physics
|May 3, 2013
PubMed
Summary
This summary is machine-generated.

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This study introduces a new trimodal small animal imaging system combining positron emission tomography (PET), single photon emission computed tomography (SPECT), and computed tomography (CT). The developed PET/SPECT/CT scanner offers high-quality imaging performance for small animal research.

Area of Science:

  • Medical Imaging
  • Biomedical Engineering
  • Small Animal Research

Background:

  • Multimodal imaging systems offer complementary information for small animal studies.
  • Existing systems may face limitations in resolution, sensitivity, or cost-effectiveness.

Purpose of the Study:

  • To design and evaluate a novel trimodal PET/SPECT/CT scanner for small animal imaging.
  • To assess the performance characteristics of the integrated system.

Main Methods:

  • Developed a trimodal system with monolithic crystal-based PET and SPECT subsystems and a microfocus X-ray tube-based CT.
  • Utilized cone-beam geometry for CT with a rotating tube and detector.
  • Employed dual-head SPECT detectors and an octagonal PET module configuration.
  • Reconstructed images using 3D MLEM/OSEM for PET/SPECT and 3D FBP for CT.

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Main Results:

  • Achieved CT spatial resolution of 85 μm and uniformity of 2.7%.
  • SPECT spatial resolution better than 0.8 mm and system sensitivity of 700 cps/MBq with a multi-pinhole collimator.
  • PET radial spatial resolution of 1.55 mm at the center of the FOV and absolute sensitivity of 2%.
  • Demonstrated high-quality images suitable for small animal studies.

Conclusions:

  • The developed small animal PET/SPECT/CT system exhibits high performance and produces high-quality images.
  • The monolithic design for PET and SPECT scintillator crystals reduces cost and complexity without significant performance degradation.