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[Severe tetanus and intrathecal baclofen].

J M Saissy¹, O Raux, R Gohard

¹Service de Réanimation, Hôpital Principal, Dakar, Sénégal.

Annales Francaises D'Anesthesie Et De Reanimation

|January 1, 1990

Summary

Subarachnoid baclofen effectively controlled severe tetanus-induced spasticity in a case report. This treatment approach offers a promising alternative for managing refractory muscle spasms in tetanus patients.

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Area of Science:

Neurology
Pharmacology
Critical Care Medicine

Background:

Tetanus is a severe neurotoxic disease characterized by muscle rigidity and spasms.
Conventional treatments for severe tetanus may not always adequately control refractory spasticity.
Intrathecal baclofen has shown efficacy in managing spasticity in other neurological conditions.

Observation:

A 48-year-old male patient with severe tetanus presented with significant spasticity.
An epidural catheter was placed for subarachnoid administration of baclofen.
Initial bolus injections of baclofen were administered, followed by a continuous infusion.

Findings:

Subarachnoid baclofen administration, initiated with two 1 mg injections and maintained with a continuous infusion of 2 mg/24h over 20 days, efficiently controlled the patient's spasticity.
The patient experienced a favorable outcome with effective management of tetanus-related muscle spasms.

Implications:

Subarachnoid baclofen represents a potential therapeutic option for severe tetanus refractory to conventional management.
This case highlights the utility of targeted intrathecal drug delivery for controlling severe neurological symptoms.
Further research may explore the safety and efficacy of subarachnoid baclofen in larger tetanus cohorts.

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