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Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

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Related Experiment Video

Updated: May 11, 2026

Methodology for Sputum Induction and Laboratory Processing
13:28

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

Asthma exacerbations: predisposing factors and prediction rules.

Steven Greenberg1

  • 1Respiratory & Immunology, Clinical Research, Merck Research Laboratories, Kenilworth, NJ 07033, USA. steven_greenberg@merck.com

Current Opinion in Allergy and Clinical Immunology
|May 3, 2013
PubMed
Summary

Predicting asthma exacerbations is key for better patient management. This review highlights factors and clinical rules to identify individuals at high risk for severe asthma attacks.

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Area of Science:

  • Pulmonology
  • Clinical Medicine
  • Genetics

Background:

  • Asthma is a complex respiratory condition characterized by reduced lung function, diverse symptoms, and variable control.
  • Acute asthma exacerbations pose a significant risk, impacting patient management and research participant identification.

Purpose of the Study:

  • To review factors contributing to asthma exacerbations.
  • To identify clinical prediction rules for severe asthma exacerbations.

Main Methods:

  • Literature review focusing on factors associated with asthma exacerbations.
  • Analysis of biomarkers and genetic factors related to exacerbation risk.
  • Evaluation of outcome measures with predictive validity.

Main Results:

  • Exacerbation risk factors vary and do not always correlate with airway hyper-responsiveness.
  • Emerging genetic factors are linked to exacerbation risk.
  • Validated outcome measures can aid patient management and clinical trials.

Conclusions:

  • Understanding exacerbation triggers is crucial for asthma management.
  • Clinical prediction rules can identify patients at high risk for severe exacerbations.
  • This review synthesizes current knowledge on predicting asthma exacerbations.