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Related Concept Videos

Stem Cell Niche01:26

Stem Cell Niche

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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
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Liver Regeneration01:24

Liver Regeneration

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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
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Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Hematopoiesis01:21

Hematopoiesis

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Related Experiment Video

Updated: Feb 25, 2026

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells
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Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells

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Hepatic stem cell niches.

Claus Kordes1, Dieter Häussinger

  • 1Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

The Journal of Clinical Investigation
|May 3, 2013
PubMed
Summary

Special microenvironments called stem cell niches maintain tissue regeneration. In the liver, potential stem cell niches are identified in the canals of Hering and the space of Disse, supporting tissue repair and cell function.

Area of Science:

  • Hepatology and stem cell biology.
  • Investigating the cellular microenvironment of the liver.

Background:

  • Stem cell niches are crucial microenvironments regulating stem cell behavior for tissue homeostasis and regeneration.
  • The liver possesses significant regenerative capacity, particularly involving stem/progenitor cells when hepatocyte proliferation is compromised.

Purpose of the Study:

  • To identify and characterize potential stem cell niches within the liver.
  • To understand the role of these niches in liver regeneration and cellular maintenance.

Main Methods:

  • Review of recent scientific literature on hepatic stem cell niches.
  • Analysis of evidence for specific anatomical locations serving as stem cell niches.

Main Results:

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  • Potential hepatic stem cell niches have been identified.
  • Evidence suggests hepatic progenitor cells may originate from niches within the canals of Hering.
  • The space of Disse is implicated as a potential niche for fetal hematopoiesis and adult stellate cells.

    • Conclusions:

    • The canals of Hering and the space of Disse represent key areas of interest for hepatic stem cell niches.
    • These niches play a role in liver regeneration and maintaining cellular populations throughout life.