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Related Concept Videos

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...

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Related Experiment Video

Updated: May 11, 2026

Three-Dimensionally Printed Microfluidic Cross-flow System for Ultrafiltration/Nanofiltration Membrane Performance Testing
10:19

Three-Dimensionally Printed Microfluidic Cross-flow System for Ultrafiltration/Nanofiltration Membrane Performance Testing

Published on: February 13, 2016

Treatment frequency and efficiency in hemodiafiltration.

Werner Beck1, Franz Techert, Heike Lebsanft

  • 1Gambro Dialysatoren GmbH, Hechingen, Germany. werner.beck @ gambro.com

Blood Purification
|May 3, 2013
PubMed
Summary

More frequent hemodiafiltration (HDF) treatments improve blood purification. Two 2-hour HDF sessions daily lowered uremic toxins more effectively than one 4-hour session, optimizing patient outcomes.

Related Experiment Videos

Last Updated: May 11, 2026

Three-Dimensionally Printed Microfluidic Cross-flow System for Ultrafiltration/Nanofiltration Membrane Performance Testing
10:19

Three-Dimensionally Printed Microfluidic Cross-flow System for Ultrafiltration/Nanofiltration Membrane Performance Testing

Published on: February 13, 2016

Area of Science:

  • Nephrology
  • Renal Replacement Therapy
  • Biomedical Engineering

Background:

  • Dialysis aims to eliminate uremic retention products, but efficiency varies by modality.
  • Hemodiafiltration (HDF) is a dialysis technique with varying solute removal capabilities.
  • Intermittent treatment schedules require analysis of solute kinetics.

Purpose of the Study:

  • To compare the efficacy of intermittent hemodiafiltration (HDF) schedules.
  • To analyze plasma concentrations of marker solutes under different HDF treatment frequencies.
  • To determine optimal blood purification strategies in HDF therapy.

Main Methods:

  • 10 patients underwent postdilution HDF in two regimens: one 4-hour session vs. two 2-hour sessions on consecutive days.
  • Plasma levels of urea, creatinine, phosphate, β2-microglobulin, complement factor D, and advanced glycation end products were measured.
  • Solute elimination and rebound kinetics were monitored for 24-48 hours post-treatment.

Main Results:

  • Two 2-hour HDF treatments significantly reduced plasma levels of urea, creatinine, phosphate, β2-microglobulin, and advanced glycation end products.
  • This effect was more pronounced at 48 hours compared to a single 4-hour session.
  • Reduced solute rebound was observed with increased treatment frequency.

Conclusions:

  • Increased treatment frequency in HDF therapy can enhance blood purification.
  • Optimizing HDF schedules by increasing frequency may improve uremic toxin clearance.
  • Further research into treatment frequency could refine HDF protocols.