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Breast-conserving therapy for macroscopically multiple cancers
J M Kurtz1, J Jacquemier, R Amalric
1Académie Méditerranéenne d'Oncologie Clinique, Marseille, France.
Annals of Surgery
|July 1, 1990
Summary
Macroscopically multiple breast cancers increase local recurrence risk after conservative surgery and radiotherapy. Early detection and clear surgical margins are crucial for better outcomes in these patients.
Area of Science:
- Oncology
- Surgical Oncology
- Radiotherapy
Background:
- Stage I-II breast cancers are often treated with conservative surgery and radiotherapy.
- The presence of multiple macroscopic tumor nodules can affect treatment outcomes.
Purpose of the Study:
- To evaluate the local failure risk in patients with unilateral, stage I-II breast cancer exhibiting multiple macroscopic tumor nodules.
- To identify factors influencing local recurrence in these patients.
Main Methods:
- Retrospective analysis of 586 patients with unilateral stage I-II breast cancer.
- Comparison of local recurrence rates between patients with single and multiple tumors.
- Analysis of factors including diagnosis method, number of nodules, and resection margins.
Main Results:
- Patients with multiple tumors had a significantly higher local recurrence rate (25%) compared to single tumors (11%).
- Higher recurrence rates were observed when multiplicity was clinically apparent or involved three or more nodules.
- Negative resection margins were associated with significantly lower local failure rates.
Conclusions:
- Macroscopically multiple breast cancers are associated with an elevated risk of local failure.
- Clinical detection of multiplicity and a higher number of nodules increase this risk.
- Achieving negative resection margins is critical for improving outcomes in patients with multiple breast tumors.