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Related Concept Videos

Systematic Error: Methodological and Sampling Errors01:15

Systematic Error: Methodological and Sampling Errors

In the case of systematic errors, the sources can be identified, and the errors can be subsequently minimized by addressing these sources. According to the source, systematic errors can be divided into sampling, instrumental, methodological, and personal errors.
Sampling errors originate from improper sampling methods or the wrong sample population. These errors can be minimized by refining the sampling strategy. Defective instruments or faulty calibrations are the sources of instrumental...

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Related Experiment Video

Updated: May 11, 2026

Use of Magnetic Resonance Imaging and Biopsy Data to Guide Sampling Procedures for Prostate Cancer Biobanking
05:49

Use of Magnetic Resonance Imaging and Biopsy Data to Guide Sampling Procedures for Prostate Cancer Biobanking

Published on: October 10, 2019

Mitochondria, prostate cancer, and biopsy sampling error.

Ryan L Parr1, John Mills, Andrew Harbottle

  • 1Department of Research, Mitomics Inc., Suite 1000, 290 Munro St., Thunder Bay, Ontario P7A 7T1, Canada.

Discovery Medicine
|May 3, 2013
PubMed
Summary

Mitochondrial DNA alterations are key indicators in prostate cancer, impacting cell growth, metastasis, and treatment response. Research highlights their potential in diagnostics and predicting patient outcomes.

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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

Area of Science:

  • Mitochondrial biology
  • Cancer genomics
  • Prostate cancer research

Background:

  • Mitochondria and their genome (mtgenome) are increasingly recognized for their role in prostate cancer.
  • MtDNA alterations are linked to cancer progression, including proliferation, metastasis, and androgen independence.
  • Specific mtgenome mutations correlate with prostate-specific antigen (PSA) levels and a large deletion suggests a field effect in prostate cancer.

Purpose of the Study:

  • To review the biological characteristics of mitochondria in prostate cancer.
  • To explore the direct clinical applications of mitochondrial science in prostate cancer diagnostics.
  • To highlight the emerging role of mitochondrial research in oncology.

Main Methods:

  • Review of current literature on mitochondrial genetics and prostate cancer.
  • Analysis of associations between mtgenome alterations and clinical parameters.
  • Discussion of diagnostic and prognostic implications.

Main Results:

  • Somatic mutation patterns in complete mtgenomes correlate with PSA levels.
  • A 3.4 kb mtgenome deletion is associated with prostate cancer 'cancerization' field effect.
  • Mitochondrial alterations are implicated in key cancer behaviors like proliferation and apoptosis signaling.

Conclusions:

  • Mitochondrial genome alterations are sophisticated indicators of prostate cancer biology.
  • Mitochondrial science is actively influencing prostate cancer diagnostics.
  • Future breakthroughs in oncology are anticipated from ongoing mitochondrial research.