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Related Experiment Video

Updated: May 11, 2026

Generation of Human Kidney Tubuloids from Tissue and Urine

Generation of Human Kidney Tubuloids from Tissue and Urine

Published on: April 16, 2021

Renal tubular dysgenesis.

Marie-Claire Gubler¹

¹INSERM, U983, 149 rue de Sèvres, 75743, Paris cedex 15, France, marie-claire.gubler@inserm.fr.

Pediatric Nephrology (Berlin, Germany)

|May 3, 2013

Summary

Renal tubular dysgenesis (RTD) is a severe fetal disorder impacting kidney development. Early diagnosis of RTD in an anuric fetus is crucial for management and genetic counseling.

Area of Science:

Perinatology
Nephrology
Genetics

Background:

Renal tubular dysgenesis (RTD) is a severe fetal disorder characterized by absent or poorly developed proximal tubules, leading to anuria and Potter sequence.
Affected fetuses often experience early death due to pulmonary hypoplasia, anuria, and refractory arterial hypotension.
RTD can be inherited as an autosomal recessive disease or acquired during fetal development.

Purpose of the Study:

To summarize the key features, causes, and implications of renal tubular dysgenesis (RTD).
To highlight the critical role of the renin-angiotensin system (RAS) in fetal renal development and blood pressure regulation.
To emphasize the importance of diagnosing RTD in anuric fetuses for appropriate management and counseling.

Main Methods:

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Review of existing literature on renal tubular dysgenesis (RTD).

Analysis of genetic mutations associated with inherited RTD within the renin-angiotensin system (RAS).

Examination of secondary causes of RTD, including twin-to-twin transfusion syndrome and exposure to RAS blockers.

Main Results:

Mutations in RAS components (angiotensinogen, renin, ACE, AT1R) cause inherited RTD by disrupting angiotensin II production or function.
Secondary RTD results from conditions causing fetal renal hypoperfusion, such as twin-to-twin transfusion syndrome or exposure to RAS inhibitors.
A functional RAS is vital for maintaining fetal blood pressure and renal blood flow.

Conclusions:

Accurate diagnosis of RTD in an anuric fetus with normal renal sonography is essential for neonatal management.
Understanding the cause of RTD allows for genetic counseling and strategies to prevent recurrence in future pregnancies.
RTD underscores the critical importance of the renin-angiotensin system for normal fetal development and survival.