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A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

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Published on: June 4, 2021

Prothrombotic states in migraine.

Roopa Rajan¹, Jasmina Ahluwalia², Vivek Lal³

¹Department of Neurology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

|May 3, 2013

Summary

This summary is machine-generated.

Migraine patients do not show a higher prevalence of prothrombotic states, which are linked to cardiovascular risks. This study found no significant difference compared to headache-free individuals.

Keywords:

cardiovascular cerebrovascular migraine prothrombotic states stroke

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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Area of Science:

Neurology
Hematology
Cardiovascular Medicine

Background:

Patients with migraine have an elevated risk of cardiovascular and cerebrovascular events.
Prothrombotic states are suspected contributors to this increased risk, but their prevalence in migraineurs is unclear.

Purpose of the Study:

To compare the prevalence of prothrombotic states in patients diagnosed with migraine versus headache-free controls.
To investigate whether specific prothrombotic factors are more common in individuals experiencing migraines.

Main Methods:

A case-control study design was employed.
Screening for prothrombotic states included protein C, protein S (PS) deficiency, antithrombin III, factor V Leiden mutation, lupus anticoagulant, anticardiolipin antibodies, and anti-β2-glycoprotein 1 antibodies.
The study included 101 consecutive patients with migraine and 148 headache-free controls.

Main Results:

An underlying prothrombotic state was identified in 11.8% of patients with migraine.
Protein S (PS) deficiency was the most frequent prothrombotic state observed in migraine patients at 4.0%.
No statistically significant difference was found in the overall prevalence of prothrombotic states between the migraine group and the control group.

Conclusions:

Traditional prothrombotic states do not appear to be more prevalent in patients with migraine compared to individuals without migraines.
The findings suggest that common prothrombotic states do not explain the increased cardiovascular and cerebrovascular risk associated with migraine.
Further research is needed to elucidate the mechanisms behind the heightened risk of vascular events in migraine patients.