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Prothrombotic states in migraine

Roopa Rajan1, Jasmina Ahluwalia2, Vivek Lal3

  • 1Department of Neurology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|May 3, 2013
PubMed

Insights

Migraine patients do not show a higher prevalence of prothrombotic states, which are linked to cardiovascular risks. This study found no significant difference compared to headache-free individuals.

Area of Science:

  • Neurology
  • Hematology
  • Cardiovascular Medicine

Background:

  • Patients with migraine have an elevated risk of cardiovascular and cerebrovascular events.
  • Prothrombotic states are suspected contributors to this increased risk, but their prevalence in migraineurs is unclear.

Purpose of the Study:

  • To compare the prevalence of prothrombotic states in patients diagnosed with migraine versus headache-free controls.
  • To investigate whether specific prothrombotic factors are more common in individuals experiencing migraines.

Main Methods:

  • A case-control study design was employed.
  • Screening for prothrombotic states included protein C, protein S (PS) deficiency, antithrombin III, factor V Leiden mutation, lupus anticoagulant, anticardiolipin antibodies, and anti-β2-glycoprotein 1 antibodies.
  • The study included 101 consecutive patients with migraine and 148 headache-free controls.

Main Results:

  • An underlying prothrombotic state was identified in 11.8% of patients with migraine.
  • Protein S (PS) deficiency was the most frequent prothrombotic state observed in migraine patients at 4.0%.
  • No statistically significant difference was found in the overall prevalence of prothrombotic states between the migraine group and the control group.

Conclusions:

  • Traditional prothrombotic states do not appear to be more prevalent in patients with migraine compared to individuals without migraines.
  • The findings suggest that common prothrombotic states do not explain the increased cardiovascular and cerebrovascular risk associated with migraine.
  • Further research is needed to elucidate the mechanisms behind the heightened risk of vascular events in migraine patients.

Keywords:
cardiovascularcerebrovascularmigraineprothrombotic statesstroke

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