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Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
Published on: February 22, 2019
Vaccines, reverse vaccinology, and bacterial pathogenesis
Isabel Delany1, Rino Rappuoli, Kate L Seib
1Novartis Vaccines and Diagnostics, 53100 Siena, Italy.
Cold Spring Harbor Perspectives in Medicine
|May 3, 2013
Summary
Genomic approaches and reverse vaccinology accelerate the discovery of novel vaccine candidates. Studying pathogen virulence factors, like meningococcus fHbp, enhances understanding of disease and guides next-generation vaccine design.
Area of Science:
- Genomics
- Vaccinology
- Pathogen Biology
Background:
- Genomics and reverse vaccinology are revolutionizing vaccine development.
- Novel antigen discovery offers new insights into pathogen mechanisms.
Purpose of the Study:
- To illustrate how genomic strategies identify and exploit novel vaccine candidates.
- To demonstrate the role of pathogen virulence factors in vaccine design.
Main Methods:
- Genome mining for novel antigens.
- Characterization of virulence factors, exemplified by fHbp in meningococcus.
Main Results:
- Identification of fHbp as a key meningococcal virulence factor and vaccine candidate.
- Genomic analysis reveals new aspects of pathogen pathogenesis.
Conclusions:
- Genomic approaches enhance understanding of pathogen biology and host immunity.
- Rational design of next-generation vaccines is guided by pathogen genomics and virulence factor analysis.
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