Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Estimation of the Physical Quantities01:05

Estimation of the Physical Quantities

On many occasions, physicists, other scientists, and engineers need to make estimates of a particular quantity. These are sometimes referred to as guesstimates, order-of-magnitude approximations, back-of-the-envelope calculations, or Fermi calculations. The physicist Enrico Fermi was famous for his ability to estimate various kinds of data with surprising precision. Estimating does not mean guessing a number or a formula at random. Instead, estimation means using prior experience and sound...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of microglial cell population expansion in the <i>Tg344-AD</i> rat and <i>APP<sub>SWE</sub>/PS1<sub>ΔE9</sub></i> mouse model of Alzheimer's disease.

Journal of Alzheimer's disease reports·2025
Same author

The porcine corticospinal decussation: A combined neuronal tracing and tractography study.

Brain research bulletin·2018
Same author

Space Balls Revisited: Stereological Estimates of Length With Virtual Isotropic Surface Probes.

Frontiers in neuroanatomy·2018
Same author

Disturbances in the control of capillary flow in an aged APP<sup>swe</sup>/PS1ΔE9 model of Alzheimer's disease.

Neurobiology of aging·2017
Same author

Neuron and neuroblast numbers and cytogenesis in the dentate gyrus of aged APP<sub>swe</sub>/PS1<sub>dE9</sub> transgenic mice: Effect of long-term treatment with paroxetine.

Neurobiology of disease·2017
Same author

Stereological investigation of the CA1 pyramidal cell layer in untreated and lithium-treated 3xTg-AD and wild-type mice.

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft·2016
Same journal

High-Throughput Microbial Assay for Amino Acid Measurement in Ground Maize Seed Samples Utilizing Auxotrophic <i>E. coli</i>.

Cold Spring Harbor protocols·2025
Same journal

Grain Quality in Maize.

Cold Spring Harbor protocols·2025
Same journal

High-Throughput Assay for Measuring Phytate and Available Phosphorus in Ground Maize Seed Samples.

Cold Spring Harbor protocols·2025
Same journal

Functional Genomic Analysis of Transposon Insertion Mutant Maize Plants from the UniformMu National Public Resource.

Cold Spring Harbor protocols·2025
Same journal

The UniformMu National Public Resource: Transposon<i>-</i>Induced Mutant Seeds for Functional Genomics Studies in Maize.

Cold Spring Harbor protocols·2025
Same journal

Insights from the Study of B<i>-</i>Cell Epitopes of a Microbial Pathogen by Phage Display.

Cold Spring Harbor protocols·2025
See all related articles

Related Experiment Video

Updated: May 11, 2026

Stereological Estimation of Cholinergic Fiber Length in the Nucleus Basalis of Meynert of the Mouse Brain
09:15

Stereological Estimation of Cholinergic Fiber Length in the Nucleus Basalis of Meynert of the Mouse Brain

Published on: February 5, 2020

Estimating length in biological structures.

Mark J West

    Cold Spring Harbor Protocols
    |May 3, 2013
    PubMed
    Summary
    This summary is machine-generated.

    Estimating biological tissue length is now easier with the virtual isotropic spaceball probe. This method simplifies measurements of linear features in complex structures like the human hippocampus.

    More Related Videos

    Kinematic Analysis of Cell Division and Expansion: Quantifying the Cellular Basis of Growth and Sampling Developmental Zones in Zea mays Leaves
    08:31

    Kinematic Analysis of Cell Division and Expansion: Quantifying the Cellular Basis of Growth and Sampling Developmental Zones in Zea mays Leaves

    Published on: December 2, 2016

    Quantitative Approaches for Studying Cellular Structures and Organelle Morphology in Caenorhabditis elegans
    08:47

    Quantitative Approaches for Studying Cellular Structures and Organelle Morphology in Caenorhabditis elegans

    Published on: July 5, 2019

    Related Experiment Videos

    Last Updated: May 11, 2026

    Stereological Estimation of Cholinergic Fiber Length in the Nucleus Basalis of Meynert of the Mouse Brain
    09:15

    Stereological Estimation of Cholinergic Fiber Length in the Nucleus Basalis of Meynert of the Mouse Brain

    Published on: February 5, 2020

    Kinematic Analysis of Cell Division and Expansion: Quantifying the Cellular Basis of Growth and Sampling Developmental Zones in Zea mays Leaves
    08:31

    Kinematic Analysis of Cell Division and Expansion: Quantifying the Cellular Basis of Growth and Sampling Developmental Zones in Zea mays Leaves

    Published on: December 2, 2016

    Quantitative Approaches for Studying Cellular Structures and Organelle Morphology in Caenorhabditis elegans
    08:47

    Quantitative Approaches for Studying Cellular Structures and Organelle Morphology in Caenorhabditis elegans

    Published on: July 5, 2019

    Area of Science:

    • Neuroscience
    • Stereology
    • Biophysics

    Background:

    • Accurate length estimation of biological tissues is crucial for understanding function.
    • Traditional methods face challenges due to the anisotropic orientation of cellular and tissue structures.
    • Difficulties in achieving isotropic interaction limit unbiased stereological studies, especially in complex brain regions.

    Purpose of the Study:

    • To introduce and describe the application of the virtual isotropic spherical probe (spaceball) for length estimation.
    • To demonstrate the utility of the spaceball probe in overcoming limitations of traditional stereological methods.
    • To provide an example of estimating total capillary length in a specific human hippocampal subregion.

    Main Methods:

    • Utilized a virtual isotropic spherical probe (spaceball) to achieve isotropic interaction with tissue structures.
    • Applied the spaceball probe for length estimation in biological samples.
    • Focused on estimating total capillary length within the CA1 stratum radiatum of the human hippocampus.

    Main Results:

    • The spaceball probe facilitates isotropic interaction, simplifying length estimation.
    • Successfully estimated the total capillary length in the CA1 stratum radiatum.
    • Demonstrated a more accessible approach to unbiased stereological length measurements.

    Conclusions:

    • The spaceball probe offers a practical solution for estimating the length of linear features in biological tissues.
    • This method enhances the feasibility of unbiased stereological studies, particularly for complex structures.
    • The technique holds potential for advancing research in neuroanatomy and vascular biology.