Related Experiment Video
Updated: May 11, 2026

Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes
Published on: September 27, 2014
Host IQGAP1 and Ebola virus VP40 interactions facilitate virus-like particle egress
Jianhong Lu1, Yonggang Qu, Yuliang Liu
1Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Abstract:
We have identified host IQGAP1 as an interacting partner for Ebola virus (EBOV) VP40, and its expression is required for EBOV VP40 virus-like particle (VLP) budding. IQGAP1 is involved in actin cytoskeletal remodeling during cell migration and formation of filopodia. The physical interaction and the functional requirement for IQGAP1 in EBOV VP40 VLP egress link virus budding to the cytoskeletal remodeling machinery. Consequently, this interaction represents a novel target for development of therapeutics to block budding and transmission of filoviruses.
Related Concept Videos
Leaky Scanning
Viruses with RNA Genomes
Intralumenal Vesicles and Multivesicular Bodies
Viral Recombination

