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Negative association between testosterone concentration and inflammatory markers in young men: a nested
Johannes Bobjer1, Marianna Katrinaki, Christos Tsatsanis
1Reproductive Medicine Centre, Skåne University Hospital Malmö, Malmö, Sweden. johannes.bobjer@med.lu.se
Plos One
|May 3, 2013
Summary
Low testosterone levels in young men are linked to low-grade systemic inflammation (LGSI) biomarkers. This association may explain adverse health outcomes linked to male hypogonadism.
Area of Science:
- Endocrinology
- Immunology
- Men's Health
Background:
- Low-grade systemic inflammation (LGSI) and androgen deficiency are linked to pathologies in older men, including cardiovascular disease (CVD).
- Investigating early-life associations between testosterone and LGSI is crucial for understanding long-term health risks.
Purpose of the Study:
- To determine if low testosterone levels in young men are associated with biomarkers of LGSI.
- To explore potential mechanisms linking male hypogonadism to adverse health outcomes.
Main Methods:
- Nested cross-sectional study involving 60 men (20 hypogonadal, 20 eugonadal, 20 controls), mean age 37 years.
- Assessed serum levels of testosterone, LH, estradiol, SHBG, and 21 LGSI markers.
- Included anthropometric measures and interviews.
Main Results:
- Macrophage inflammatory protein 1-alpha (MIP1a), MIP1-beta, and tumor necrosis factor alpha (TNFa) showed negative associations with total testosterone (TT) and calculated free testosterone (cFT).
- Men with subnormal TT and cFT levels exhibited higher TNFa and MIP1a levels compared to those with normal levels.
- These findings suggest a link between low testosterone and inflammatory markers even in young adulthood.
Conclusions:
- Subnormal testosterone levels in young men may be associated with LGSI.
- This association could be a contributing factor to the adverse health outcomes observed in male hypogonadism.
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