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Relationships between exhaled nitric oxide and atopy profiles in children with asthma

Won-Nyung Jang1, In-Su Park, Chang-Hee Choi

  • 1Department of Pediatrics, Hanil General Hospital, Seoul, Korea.

Allergy, Asthma & Immunology Research
|May 3, 2013
PubMed

Insights

Fractional exhaled nitric oxide (FeNO) levels in asthmatic children increase with atopy severity. Poly-sensitized children show the highest FeNO, indicating greater airway inflammation and risk.

Area of Science:

  • Pediatric Allergy and Immunology
  • Respiratory Medicine
  • Clinical Diagnostics

Background:

  • Asthma is a chronic respiratory disease often linked to allergic sensitization (atopy).
  • Fractional exhaled nitric oxide (FeNO) is a biomarker for eosinophilic airway inflammation.
  • Understanding the relationship between atopy profiles and FeNO can refine asthma management.

Purpose of the Study:

  • To investigate the association between fractional exhaled nitric oxide (FeNO) levels and atopy profiles in asthmatic children.
  • To differentiate FeNO levels in children with non-sensitization, mono-sensitization, and poly-sensitization to common aeroallergens.

Main Methods:

  • 119 asthmatic children underwent FeNO measurement, spirometry, methacholine challenge, and blood tests (eosinophils, total IgE, ECP).
  • Skin prick testing assessed sensitization to five aeroallergen classes (mites, danders, pollens, molds, cockroaches).
  • Participants were categorized into non-sensitized, mono-sensitized, and poly-sensitized groups based on allergy test results.

Main Results:

  • Significant differences in FeNO levels were observed across the three atopy groups (P=0.001).
  • FeNO geometric means were 18.6 ppb (non-sensitized), 28.8 ppb (mono-sensitized), and 44.7 ppb (poly-sensitized).
  • FeNO showed moderate correlations with serum total IgE, blood eosinophil count, and serum eosinophil cationic protein (ECP).

Conclusions:

  • FeNO levels correlate with the degree of atopy in asthmatic children.
  • Poly-sensitized children exhibit higher FeNO levels, suggesting increased airway inflammation.
  • FeNO serves as a valuable indicator of allergic sensitization and potential airway inflammation in pediatric asthma.
Abstract

Keywords:
Atopyasthmachildfractional exhaled nitric oxidemono-sensitizationpoly-sensitization

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