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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
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Cancer Stem Cells and Tumor Maintenance

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Related Experiment Video

Updated: May 11, 2026

A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells

A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells

Published on: October 16, 2018

T-cell tolerance in cancer.

Roza Nurieva¹, Junmei Wang¹, Anupama Sahoo¹

¹Department of Immunology & Center for Inflammation & Cancer, MD Anderson Cancer Center, Houston, TX 77030, USA.

|May 4, 2013

Summary

T-cell tolerance is crucial for preventing autoimmunity but aids cancer growth. Understanding and manipulating these mechanisms can help break cancer

Area of Science:

Immunology
Cancer Biology
Cellular Mechanisms

Background:

T cells regulate adaptive immunity and tolerance prevents autoimmunity.
Tumor microenvironments promote T-cell tolerance, facilitating cancer progression.
Recent advances illuminate intrinsic and extrinsic T-cell tolerance pathways.

Purpose of the Study:

To review the mechanisms of T-cell tolerance.
To explore how tumor microenvironments exploit T-cell tolerance.
To highlight potential strategies for overcoming T-cell tolerance in cancer.

Main Methods:

Review of intrinsic extracellular and intracellular mechanisms of T-cell tolerance.
Analysis of extrinsic mechanisms involving regulatory T cells and dendritic cells.

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Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

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A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells

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Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

Examination of T-cell tolerance in the context of carcinogenesis.

Main Results:

T-cell tolerance involves complex extracellular and intracellular signaling.
Tumor-associated immune cells like Tregs and tolerogenic DCs enforce tolerance.
Multiple molecular pathways contribute to maintaining T-cell tolerance in cancer.

Conclusions:

Understanding T-cell tolerance is key to cancer immunotherapy.
Targeting T-cell tolerance mechanisms may reverse immune suppression in tumors.
Manipulating T-cell tolerance offers a promising therapeutic avenue for cancer treatment.