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Updated: May 11, 2026

The Successive Alleys Test of Anxiety in Mice and Rats
05:05

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Published on: June 17, 2013

An EJC factor RBM8a regulates anxiety behaviors.

A Alachkar1, D Jiang, M Harrison

  • 1Department of Biology, Penn State University, University Park, PA 16802, USA.

Current Molecular Medicine
|May 4, 2013
PubMed
Summary

Overexpression of RBM8a, a key factor in nonsense-mediated mRNA decay (NMD), in mice brains increased anxiety and altered social behaviors. This suggests NMD pathway

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Neuroplasticity requires precise gene expression timing, regulated by mRNA stability and degradation.
  • Nonsense-mediated mRNA decay (NMD) is crucial for degrading aberrant mRNAs and relies on Exon Junction Complex (EJC) factors.
  • Mutations in NMD factor Upf3b and its binding partner RBM8a are linked to neurodevelopmental and psychiatric disorders.

Purpose of the Study:

  • To investigate the role of RBM8a, a core EJC component, in regulating affective behaviors.
  • To explore the molecular mechanisms underlying RBM8a's influence on behavior.

Main Methods:

  • Overexpression of RBM8a in the mouse hippocampus using lentivirus infusion.
  • Behavioral assessments including social interaction, open field, elevated plus maze, and forced swimming tests.
  • Electrophysiological recordings of miniature excitatory postsynaptic currents (mEPSCs) in cultured neurons.
  • RNA-immunoprecipitation (RNA-IP) to identify RBM8a-bound mRNAs.

Main Results:

  • RBM8a overexpression in the dentate gyrus (DG) induced anxiety-like behavior and abnormal social interaction.
  • Mice with RBM8a overexpression showed decreased immobility time in the forced swimming test (FST).
  • Neuron cultures overexpressing RBM8a exhibited increased mEPSC frequency, indicating enhanced excitatory synaptic transmission.
  • RNA-IP revealed that RBM8a binds to CaMK2, GluR1, and Egr1 mRNAs, suggesting regulation of key neuronal genes.

Conclusions:

  • RBM8a plays a significant role in modulating emotional and social behaviors in mice.
  • RBM8a overexpression impacts neuronal excitability and targets specific mRNAs involved in neuronal function.
  • These findings reveal novel neural mechanisms of NMD in behavior regulation and offer insights into psychiatric disorders.