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Related Concept Videos

Biosynthesis of Nucleic Acids01:28

Biosynthesis of Nucleic Acids

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Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...
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The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
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Nucleic Acids02:43

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
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ATP and Macromolecule Synthesis01:28

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Biological macromolecules are organic compounds, predominantly composed of carbon atoms. The carbon atoms are covalently bonded with hydrogen, oxygen, nitrogen, and other minor elements. There are four major biological macromolecule classes: carbohydrates, lipids, proteins, and nucleic acids.
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Nucleic Acids and Nucleotides01:20

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and have instructions for its functioning. The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).
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Related Experiment Video

Updated: Jan 18, 2026

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
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Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides

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Polymer-assisted structural modification on nucleosides and nucleotides.

Peng Zhao1, Lihe Zhang

  • 1Department of Biochemistry, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, United States of America. Peng.Zhao@tufts.edu

Nucleosides, Nucleotides & Nucleic Acids
|May 4, 2013
PubMed
Summary
This summary is machine-generated.

Polymer-assisted synthesis rapidly creates nucleoside libraries for research and therapeutics. Solid-phase methods offer improved selectivity over traditional solution-phase techniques for nucleoside modification.

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Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
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Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
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Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
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Area of Science:

  • Biochemistry
  • Medicinal Chemistry
  • Organic Synthesis

Background:

  • Nucleosides and their analogues are crucial in biological research and therapeutic applications.
  • Developing efficient methods for nucleoside modification is essential for drug discovery and development.

Purpose of the Study:

  • To explore polymer-assisted synthesis for rapid nucleoside library construction.
  • To evaluate the advantages of solid-phase synthesis for nucleoside modifications.

Main Methods:

  • Utilizing polymer-assisted techniques for parallel synthesis of nucleoside libraries.
  • Comparing solid-phase synthesis with classic solution-phase synthesis for nucleoside modifications.

Main Results:

  • Demonstrated the capability of polymer-assisted synthesis for rapid and parallel construction of nucleoside libraries.
  • Showcased enhanced chemical and regioselectivity in solid-phase synthesis of certain nucleosides compared to solution-phase methods.

Conclusions:

  • Polymer-assisted synthesis is a powerful tool for generating diverse nucleoside libraries.
  • Solid-phase synthesis provides superior selectivity for specific nucleoside modifications, advancing therapeutic development.