Related Experiment Video
Updated: May 11, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Indanomycin-related antibiotics from marine Streptomyces antibioticus PTZ0016
Xiao-Yuan Lian1, Zhizhen Zhang
1a College of Pharmaceutical Sciences, Zhejiang University , Hangzhou , 310058 , P.R. China.
Abstract:
Four indanomycin-related antibiotics 2-5 were isolated from the cultured broth of marine Streptomyces antibioticus strain PTZ0016. Their structures were characterised as 16-deethylindanomycin (2), iso-16-deethylindanomycin (3), 16-deethylindanomycin methyl ester (4) and iso-16-deethylindanomycin methyl ester (5) on the basis of NMR, HR-ESI-MS and CD evidences. Compounds 3-5 are new additions to the class of indanomycin antibiotics. All isolated compounds showed in vitro activity against Staphylococcus aureus with minimal inhibitory concentration at 4.0-8.0 μg/ml.
Related Concept Videos
Clinical Significance of Antibiotic Resistance
Production of Antibiotics
Inhibitors of Bacterial Protein Synthesis
Antibiotic Selection
Inhibitors of Gram-positive Cell Wall Synthesis
Gene Regulation in Microbial Communities: Quorum Sensing

