Related Experiment Video
Updated: May 11, 2026

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
Published on: February 6, 2019
Resting state synchrony in long-term abstinent alcoholics with versus without comorbid drug dependence
Jazmin Camchong1, Victor Andrew Stenger, George Fein
1Neurobehavioral Research, Inc., 1585 Kapiolani Blvd., Honolulu, HI 96814, USA. jcamchong@nbresearch.com
Background:
We previously reported that when long-term abstinent alcoholics (LTAA; with no drug comorbidity) are compared to controls, they show increased resting state synchrony (RSS) in the executive control network and reduced RSS in the appetitive drive network suggestive of compensatory mechanisms that may facilitate abstinence. The aim of the present study was to investigate whether long-term abstinent alcoholics with comorbid stimulants dependence (LTAAS) show similar RSS mechanisms.
Methods:
Resting-state functional MRI data were collected on 36 LTAAS (20 females, age: 47.85±7.30), 23 LTAA (8 females, age: M=47.91±6.76), and 23 non-substance abusing controls (NSAC; 8 females, age: M=47.99±6.70). Using seed-based measures, we examined RSS with the nucleus accumbens (NAcc) and the subgenual anterior cingulate cortex (sgACC).
Results:
Results showed commonalities in LTAA and LTAAS RSS (similar enhanced executive control RSS and left insula RSS) as well as differences (no attenuation of appetitive drive RSS in LTAAS and no enhancement of RSS in right insula in LTAA).
Conclusions:
We believe these differences are adaptive mechanisms that support abstinence. These findings suggest common as well as specific targets for treatment in chronic alcoholics with vs without comorbid stimulant dependence.
More Related Videos
Related Concept Videos
Drug Dependence
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
CNS Depressants: Alcohol and Nicotine
Drug Abuse and Addiction: Pharmacological Phenomena
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Drug Concentration Versus Time Correlation
Two pivotal parameters are the minimum effective concentration (MEC) and the minimum toxic concentration (MTC). The MEC is the lowest drug...

