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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

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Related Experiment Video

Updated: May 11, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

Immune circuits in asthma.

Stephen T Holgate1

  • 1Clinical and Experimental Sciences, Mail Point 810, Level F South Block, Southampton General Hospital, Southampton SO16 6YD, UK. sth@soton.ac.uk

Current Opinion in Pharmacology
|May 4, 2013
PubMed
Summary
This summary is machine-generated.

Asthma treatment needs a personalized approach beyond severity. Identifying distinct asthma subphenotypes and their underlying immune mechanisms can guide targeted therapies for better patient outcomes.

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Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography
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Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography

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Related Experiment Videos

Last Updated: May 11, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography
08:58

Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography

Published on: July 10, 2018

Area of Science:

  • Immunology
  • Pulmonology
  • Personalized Medicine

Background:

  • Asthma is traditionally classified by severity, guiding treatment with beta2-adrenoceptor agonists and corticosteroids.
  • Current classifications do not fully account for asthma's heterogeneity and diverse causal pathways.

Purpose of the Study:

  • To review asthma subphenotypes focusing on innate immune mechanisms.
  • To advocate for a shift from adaptive to innate immune focus in understanding asthma.
  • To promote a personalized medicine approach targeting specific causal pathways.

Main Methods:

  • Literature review of asthma subphenotypes.
  • Analysis of immune mechanisms in asthma.
  • Discussion of biomarker-driven targeted therapies.

Main Results:

  • Identified distinct asthma subphenotypes with varying underlying mechanisms.
  • Highlighted the importance of innate immune pathways in asthma pathogenesis.
  • Emphasized the need for biomarker identification to guide personalized treatment.

Conclusions:

  • Asthma management requires moving beyond severity-based classification.
  • Understanding disease heterogeneity through subphenotypes and immune mechanisms is crucial.
  • Personalized medicine, targeting specific causal pathways, offers a promising future for asthma treatment.