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Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

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Published on: January 24, 2025

Crosslinked ionic polysaccharides for stimuli-sensitive drug delivery.

Carmen Alvarez-Lorenzo¹, Barbara Blanco-Fernandez, Ana M Puga

¹Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, 15782-Santiago de Compostela, Spain.

Advanced Drug Delivery Reviews

|May 4, 2013

Summary

Ionic polysaccharides form stimuli-responsive hydrogels for controlled drug delivery. These natural materials offer tunable on-off release triggered by various external and internal stimuli, enhancing drug delivery systems.

Keywords:

(dimethylamino)ethyl methacrylate 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide 5-ASA 5-aminosalicylic acid AAc Alginate BSA CM CMC CPG Carragenan Chitosan Chondroitin Controlled release DDS DE DMA DS Dextran EDC EGDE FTIC IPN LCST LDHs LbL MMT PAAm PBS PCL PEI PEO-PPO-PEO PNIPAAm PNaA PVA PVP Pectin Pyro SA SDS SGF SIF SNAP Scleroglucan Smart drug delivery systems TPP ZPG bovine serum albumin calcium pectinate carboxymethyl carboxymethyl cellulose crosslinked alginate particles degree of esterification diclofenac sodium drug delivery system ethyleneglycol diglycidylether fluorescein isothiocyanate interpenetrating network layer-by-layer layered double hydroxides lower critical solubility temperature montmorillonite pH-responsiveness phosphate buffer saline poli-ε-caprolactone poly(N-isopropylacrylamide)poly(acrylic acid)poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide)poly(sodium acrylate)poly(vinyl alcohol)polyacrylamide polyethyleneimine polyvinylpyrrolidone pyrophosphate simulated gastric fluid simulated intestinal fluid sodium alginate sodium dodecyl sulfate tripolyphosphate zinc pectinate

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Area of Science:

Biomaterials Science
Polymer Chemistry
Drug Delivery

Background:

Polysaccharides are increasingly utilized in stimuli-responsive drug delivery systems due to their natural origin and characterization.
Ionic polysaccharides can be crosslinked into hydrogels sensitive to various stimuli, enabling on-off drug release.
Modified polysaccharides (hybrids, composites, grafted polymers) enhance responsiveness and stimulus range.

Purpose of the Study:

To review the current state of crosslinked ionic polysaccharides in drug delivery systems.
To analyze their ability to regulate drug release based on diverse stimuli.
To highlight their potential in advanced drug delivery applications.

Main Methods:

Review of literature on crosslinked ionic polysaccharides for drug delivery.
Analysis of systems responding to pH, ion concentration, electric/magnetic fields, light, temperature, redox potential, and specific molecules.
Compilation of examples and applications.

Main Results:

Crosslinked ionic polysaccharides form hydrogel networks responsive to multiple stimuli.
Drug release can be modulated by changes in pH, ion concentration, electric/magnetic fields, light, temperature, redox potential, and biomolecules.
These systems demonstrate versatility for controlled drug release.

Conclusions:

Crosslinked ionic polysaccharides are effective building blocks for advanced drug delivery systems.
They enable externally activated and feedback-modulated drug release.
These materials are suitable for developing sophisticated, responsive drug delivery platforms.