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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Ischemic Stroke l: Introduction01:15

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Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...

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Related Experiment Video

Updated: May 11, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

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Published on: July 28, 2013

Geniculocalcarine tract disintegration after ischemic stroke: a diffusion tensor imaging study.

Y Zhang1, S Wan, X Zhang

  • 1Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, GuangDong, China.

AJNR. American Journal of Neuroradiology
|May 4, 2013
PubMed
Summary
This summary is machine-generated.

Diffusion tensor imaging reveals distinct disintegration patterns in geniculocalcarine tract fibers following ischemic stroke. Affected fibers show progressive changes, while unaffected ipsilateral fibers begin disintegrating later and to a lesser extent.

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Last Updated: May 11, 2026

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DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions
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DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

Published on: August 26, 2014

Area of Science:

  • Neuroimaging
  • Neurology
  • Radiology

Background:

  • Ischemic stroke can affect the geniculocalcarine tract, crucial for visual processing.
  • Understanding the tract's disintegration is vital for assessing visual deficits post-stroke.

Purpose of the Study:

  • To investigate geniculocalcarine tract disintegration using DTI parameters after unilateral occipital or temporal-occipital ischemic stroke.
  • To compare disintegration processes between infarcted and unaffected ipsilateral geniculocalcarine tract fibers.

Main Methods:

  • Seventy-one patients with ischemic stroke underwent MRI and DTI.
  • Fractional anisotropy and mean diffusivity of geniculocalcarine tract fibers were measured at multiple time points post-stroke.

Main Results:

  • Infarcted geniculocalcarine tract fibers showed significantly lower fractional anisotropy and altered mean diffusivity compared to contralateral tracts.
  • Unaffected ipsilateral fibers initially mirrored contralateral tracts but began disintegrating by the fourth week post-stroke.
  • Disintegration of infarcted fibers stabilized around eight weeks, while unaffected fibers showed slower disintegration.

Conclusions:

  • Geniculocalcarine tract fibers affected by infarction and unaffected ipsilateral fibers exhibit different disintegration timelines and severity.
  • DTI parameters can differentiate these processes, aiding in understanding visual pathway damage after stroke.