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Multiomics Analysis of TMEM200A as a Pan-Cancer Biomarker
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Potential role of annexin A7 in cancers

Chunmei Guo1, Shuqing Liu, Frederick Greenaway

  • 1Department of Biotechnology, Dalian Medical University, Dalian 116044, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|May 4, 2013
PubMed

Insights

Annexin A7 (Anxa7) plays a dual role in cancer, suppressing tumors in some cancers like glioblastoma but promoting malignancy in others such as liver and breast cancer. This review discusses its complex associations and potential as a cancer biomarker.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Annexin A7 (Anxa7) is a Ca(2+)-regulated, phospholipid-binding protein belonging to the annexin superfamily.
  • Deregulation, loss of heterozygosity (LOH), and altered subcellular localization of Anxa7 are linked to various cancer hallmarks.

Purpose of the Study:

  • To review and discuss the multifaceted roles of Annexin A7 (Anxa7) in different types of cancer.
  • To explore the potential of Anxa7 as a diagnostic, therapeutic, and prognostic biomarker for malignant tumors.

Main Methods:

  • Literature review and synthesis of existing research on Annexin A7 (Anxa7) in oncology.
  • Analysis of studies investigating the association between Anxa7 expression/alterations and cancer development, invasion, metastasis, and progression.

Main Results:

  • Anxa7 exhibits tumor-suppressive functions in glioblastoma, melanoma, and prostate cancer.
  • Conversely, Anxa7 promotes tumorigenesis and malignancy in liver, gastric, nasopharyngeal, colorectal, and breast cancers.
  • The complex and often opposing roles of Anxa7 in different cancer types are highlighted.

Conclusions:

  • Annexin A7 (Anxa7) demonstrates context-dependent functions in cancer, acting as both a tumor suppressor and a promoter.
  • Understanding these complex associations is crucial for developing Anxa7-based cancer biomarkers and therapeutic strategies.

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