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Updated: May 11, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
To be or not to be a bipolar disorder patient: problems with diagnosis
Marianna Mazza1, Marco Di Nicola, Luigi Janiri
1Department of Neurosciences, Institute of Psychiatry and Psychology, Bipolar Disorders Unit, Università Cattolica del Sacro Cuore, Rome, Italy. marianna.mazza@rm.unicatt.it
Abstract:
The diagnosis of bipolar disorder (BD) is predominantly clinical. Some authors have suggested that BD is underdiagnosed and that many patients, particularly those with major depressive disorder, actually have BD. Some studies have suggested that BD is wrongly diagnosed, probably because of the idea of a "bipolar spectrum." To address this potential overdiagnosis, clinicians should carefully and systematically assess whether symptoms are included in diagnostic criteria and include the individual context of the patient.
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