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Related Experiment Video

Updated: May 11, 2026

Pneumatically Driven Microfluidic Platform for Micro-Particle Concentration
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High throughput multilayer microfluidic particle separation platform using embedded thermoplastic-based micropumping.

Tohid Fatanat Didar1, Kebin Li, Maryam Tabrizian

  • 1Biomedical Engineering Department, McGill University, Montreal, QC H3A 2B4, Canada.

Lab on a Chip
|May 4, 2013
PubMed
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This study introduces a novel thermoplastic elastomer microfluidic device for efficient particle and cell separation. The integrated micropump enables high-throughput sorting with up to 99% efficiency, even for nanoscale particles.

Area of Science:

  • Microfluidics
  • Biotechnology
  • Materials Science

Background:

  • Particle aggregation and membrane blocking hinder high-throughput microfluidic separations.
  • Existing microfluidic devices often struggle with precise separation of nanoscale particles and biological cells.

Purpose of the Study:

  • To develop an integrated thermoplastic elastomer (TPE) based multilayer microfluidic device for high-throughput particle and cell sorting and separation.
  • To demonstrate the device's capability in separating particles of various sizes, including nanoscale, and biological cells.

Main Methods:

  • Fabrication of multilayer microfluidic device using hot-embossing lithography with TPE and polycarbonate membranes.
  • Integration of a peristaltic micropump to induce turbulence and prevent particle aggregation and membrane blocking.

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  • Characterization of pumping performance and particle separation efficiency using different membrane pore sizes (10 μm, 5 μm, 800 nm).

    • Main Results:

    • Achieved separation efficiency as high as 99% for polystyrene microbeads of different sizes.
    • Successfully separated 390 nm particles from 2 μm beads.
    • Demonstrated separation of red blood cells (6-8 μm) from osteoblasts (>10 μm), highlighting potential for biological sample analysis.
    • Device operates efficiently at flow rates up to 100 μl min⁻¹.

    Conclusions:

    • The integrated TPE microfluidic device with a peristaltic micropump offers a robust platform for high-throughput particle and cell separation.
    • The design effectively overcomes aggregation and blocking issues, enabling precise separation across a wide range of particle sizes.
    • This technology holds significant promise for applications in biological sample processing and analysis.