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Testicular function in XYY men.

A Baghdassarian, F Bayard, D S Borgaonkar

    The Johns Hopkins Medical Journal
    |January 1, 1975
    PubMed
    Summary
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    The XYY syndrome is likely diverse, with some individuals experiencing hypogonadism and impaired fertility due to germ cell maturation arrest. This study found no link between cerebral cortex activity and hormone levels in XYY men.

    Area of Science:

    • Endocrinology
    • Genetics
    • Reproductive Biology

    Background:

    • Previous studies noted wide testosterone and luteinizing hormone (LH) variations in XYY individuals.
    • Impulsive behavior in XYY subjects led to a hypothesis of cerebral cortex-hypothalamic paroxysmal activity influencing hormone levels.

    Purpose of the Study:

    • To investigate the hypothesis linking cerebral cortex activity to hormonal fluctuations in XYY subjects.
    • To assess the variability of plasma androgen and gonadotropin levels in XYY individuals compared to XY controls.
    • To explore potential causes of hormonal scatter and fertility issues in XYY men.

    Main Methods:

    • Measured plasma testosterone, dihydrotestosterone, follicle stimulating hormone (FSH), and LH in XYY and XY subjects over consecutive days and months.

    Related Experiment Videos

  • Conducted testicular biopsies, sperm counts, and meiotic studies in eight XYY men.

    • Main Results:

    • Variability in plasma androgen and gonadotropin levels was similar between XYY and XY groups, refuting the cerebral cortex activity hypothesis.
    • Eight XYY men underwent further reproductive assessments.
    • One XYY case showed two Y-chromatin bodies during meiotic studies, suggesting germ cell maturation arrest and oligospermia.

    Conclusions:

    • The hypothesis of paroxysmal cerebral cortex activity explaining hormonal scatter in XYY individuals is not supported.
    • The "XYY syndrome" appears heterogeneous, with some cases involving hypogonadism and germ cell maturation arrest.
    • Low fertility is anticipated in XYY subjects due to oligospermia, though conception can result in XY or XYY offspring.