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Lymphangiogenesis in abdominal aortic aneurysm.

D J A Scott1, C J Allen, C A Honstvet

  • 1Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics, and Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK. d.j.a.scott@leeds.ac.uk

The British Journal of Surgery
|May 4, 2013
PubMed
Summary
This summary is machine-generated.

This study found increased lymphatic vessels in abdominal aortic aneurysm (AAA) tissue, linked to inflammation. This confirms lymphangiogenesis and neovascularization are involved in AAA disease progression.

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Area of Science:

  • Vascular biology
  • Inflammatory diseases
  • Aortic pathology

Background:

  • Abdominal aortic aneurysm (AAA) is characterized by ongoing angiogenesis within an inflammatory environment.
  • Lymphangiogenesis, the formation of new lymphatic vessels, is associated with chronic inflammation but has not been demonstrated in AAA.
  • The study aimed to investigate lymphangiogenesis in AAA and its relationship with inflammation and neovascularization.

Purpose of the Study:

  • To determine the presence of lymphangiogenesis in human AAA tissue.
  • To correlate lymphangiogenesis and neovascularization with the inflammatory state in AAA.
  • To elucidate the role of vascular endothelial growth factor (VEGF) and its receptors in AAA vascularity.

Main Methods:

  • AAA tissue samples and CT images were collected from patients undergoing elective AAA repair.
  • Control samples consisted of age-matched abdominal aortic tissue.
  • Immunohistochemistry was used to quantify blood vessels (CD31, CD105), lymphatic vessels (D2-40), VEGF-A, and VEGFR-3.

Main Results:

  • AAA walls exhibited significant inflammatory infiltrate.
  • Both blood and lymphatic vessel densities were significantly increased in AAA samples compared to controls (P < 0.001 and P = 0.003, respectively).
  • Vascularization, including lymphatic vessels (D2-40), positively correlated with the extent of inflammation (ρ = 0.675, P = 0.008). Increased expression of VEGF-A and VEGFR-3 was observed in inflammatory AAA areas.

Conclusions:

  • Lymphatic vessel involvement is demonstrated in end-stage AAA disease.
  • The extent of lymphangiogenesis in AAA is associated with the degree of inflammation.
  • Neovascularization, including both blood and lymphatic vessels, plays a confirmed role in AAA pathogenesis.