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Updated: May 11, 2026

Optimizing Sample Preparation for Cryogenic Electron Microscopy
06:32

Optimizing Sample Preparation for Cryogenic Electron Microscopy

Published on: April 11, 2025

Story in a sample-the potential (and limitations) of cryo-electron microscopy applied to molecular machines

Joachim Frank1

  • 1Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, New York, NY, 10032; Department of Biological Sciences, Columbia University, New York, NY, 10027.

Biopolymers
|May 4, 2013
PubMed

Keywords:
conformational statesfree-energy landscaperibosomesingle-molecule FRET

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