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Microsurgical Creation of Giant Bifurcation Aneurysms in Rabbits for the Evaluation of Endovascular Devices
Published on: September 8, 2023
Hemodynamic changes by flow diverters in rabbit aneurysm models: a computational fluid dynamic study based on
Qinghai Huang1, Jinyu Xu, Jiyong Cheng
1Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China.
Stroke
|May 4, 2013
Summary
Flow diverters (FDs) significantly alter blood flow dynamics in aneurysms, reducing wall shear stress and inflow volume while increasing residence time. These hemodynamic changes, particularly in occluded aneurysms, correlate with improved healing outcomes after FD implantation.
Area of Science:
- Biomedical Engineering
- Medical Imaging
- Computational Fluid Dynamics
Background:
- Flow diverter (FD) effectiveness in treating aneurysms depends on their deployed structure.
- Understanding in vivo FD configurations is crucial for predicting hemodynamic outcomes.
Purpose of the Study:
- To investigate hemodynamic changes after flow diverter implantation using patient-specific models.
- To correlate in vivo FD structure with observed hemodynamic alterations and healing.
Main Methods:
- Micro-computed tomography and angiography were used to reconstruct rabbit aneurysm models.
- Computational fluid dynamic simulations analyzed hemodynamic parameters before and after FD deployment.
- Aneurysms were categorized into occluded and unoccluded groups based on follow-up angiography.
Main Results:
- FD implantation significantly reduced aneurysm sac wall shear stress and inflow volume.
- Relative residence time within the aneurysm sac significantly increased post-FD deployment.
- Occluded aneurysms showed greater increases in relative residence time and inflow volume reduction compared to unoccluded ones.
Conclusions:
- The study provides in vivo structural data of deployed FDs.
- FDs induce significant hemodynamic changes, including decreased wall shear stress and altered flow patterns.
- Enhanced hemodynamic changes in occluded aneurysms suggest a link to improved healing.
